She was born in San Miguel de Tucumán and studied literature at the University of Buenos Aires and at the Sorbonne in Paris. Orphée has lived in France, Italy, Spain and Venezuela. She married artist Miguel Ocampo in Paris but divorced him after she returned to Argentina. She published her first novel Dos veranos (Two summers) in 1956.
Orphée has published short stories and articles in various publications such as El Tiempo, Revista de Occidente, Asomante, Cuadernos, Razon and Zona Franca e Imagen.
- Uno, novel (1961), Honourable mention in the Fahril Editorial Literary Contest
- Aire tan dulce (Air so sweet), novel (1966), second prize in the Municipality of Buenos Aires
- En el fondo, novel (1969), first prize in the Municipality of Buenos Aires
- La última conquista de El Ángel (El Angel's last conquest) (1984)
- La muerte y los desencuentros (Death and missteps), novel (1990), received the Regional Prize
- Ciego del cielo (Heavenly blind), stories (1991)
- "El universo Orpheé". eternacadencia.com.ar.
- Gaceta, La. "A los 96 años murió la escritora Elvira Orphée". www.lagaceta.com.ar.
- André, María Claudia; Bueno, Eva Paulino (2014). Latin American Women Writers: An Encyclopedia. pp. 1269–76. ISBN 1317726340.
- Miller, Jane Eldridge (2001). Who's who in Contemporary Women's Writing. p. 244. ISBN 0415159806.
- Fares, Gustavo C.; Hermann, Eliana Cazaubon (1998). Contemporary Argentinean Women Writers: A Critical Anthology. p. 141. ISBN 0813015537.
- "Elvira Orphée". John Simon Guggenheim Memorial Foundation. Archived from the original on 2 April 2015.