Eugenio Siller began his career as an actor in multiple commercials, as well as a player in musical comedies and theatrical productions.
In 1998, Eugenio became part of a singing group called Klishé, along with his older brother, Mundo, and two friends. They later formed an eponymous duo named Canela later had a modelling career in Italy. He became interested in acting in 2005. He graduated from CEA, an acting school in mexico, .
In 2006, he had a breakthrough role in Rebelde, a mexican telenovela, playing the part of Luciano. He then was cast in the hit teen series, Código Postal, playing the role of a blind man named Rafael Rojas Alonso. His first leading role came in 2007, in the hit telenovelaAl Diablo con los Guapos, in which he played Alejandro Belmonte, a rebellious rich-boy who falls in love with Allison Lozz's character Milagros. In 2009, Siller starred in the telenovela Mi Pecado in the main role of Julian Huerta Almada, the love interest of Lucrecia Córdoba, played by his former CEA classmate and friend, Maite Perroni. From November 2010 to May 2011, he played the lead role of Martín Lobos on Telemundo-produced telenovela, Aurora. He starred in Telemundo's telenovela Una Maid en Manhattan as Cristóbal Parker Salas (Main Hero) along with Litzy and the telenovela aired between 2011-2012.
Eugenio Siller - Amor Sin Final – This release consists of the principal song 'Amor Sin Final' from the Telemundo telenovela Una Maid en Manhattan sung and composed by Eugenio and produced by Marco Flores.