FCRL3

FCRL3
Identifiers
Aliases	FCRL3, CD307c, FCRH3, IFGP3, IRTA3, SPAP2, Fc receptor like 3
External IDs	OMIM: 606510; HomoloGene: 76447; GeneCards: FCRL3; OMA:FCRL3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	157,700,769 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; granulocyte; ; lymph node; ; spleen; ; appendix; ; testicle; ; blood; ; epithelium of nasopharynx; ; tonsil; ; bone marrow cells;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	kinase binding; phosphatase binding; protein phosphatase binding; protein tyrosine kinase binding;
Cellular component	membrane; integral component of membrane; plasma membrane; cell surface;
Biological process	negative regulation of immunoglobulin production; positive regulation of B cell proliferation; regulation of toll-like receptor 9 signaling pathway; positive regulation of MAPK cascade; regulation of B cell differentiation; negative regulation of B cell receptor signaling pathway; regulation of B cell activation; regulation of calcium ion import; positive regulation of protein serine/threonine phosphatase activity;
	Sources:Amigo / QuickGO
Orthologs
	115352
	n/a
	ENSG00000160856
	n/a
	Q96P31
	n/a
	NM_001024667; NM_052939; NM_001320333
	n/a
	NP_001307262; NP_443171
	n/a
	Wikidata
View/Edit Human

Fc receptor-like protein 3 is a protein that in humans is encoded by the FCRL3 gene.^[3]^[4]^[5]

Interactions

FCRL3 has been shown to interact with PTPN6.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000160856 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Davis RS, Wang YH, Kubagawa H, Cooper MD (Aug 2001). "Identification of a family of Fc receptor homologs with preferential B cell expression". Proc Natl Acad Sci U S A. 98 (17): 9772–7. Bibcode:2001PNAS...98.9772D. doi:10.1073/pnas.171308498. PMC 55528. PMID 11493702.
^ Davis RS, Dennis G Jr, Kubagawa H, Cooper MD (May 2002). "Fc receptor homologs (FcRH1-5) extend the Fc receptor family". Curr Top Microbiol Immunol. 266: 85–112. doi:10.1007/978-3-662-04700-2_7. PMID 12014205.
^ "Entrez Gene: FCRL3 Fc receptor-like 3".
^ Xu, Ming-jiang; Zhao Runxiang; Cao Hongxi; Zhao Zhizhuang Joe (May 2002). "SPAP2, an Ig family receptor containing both ITIMs and ITAMs". Biochem. Biophys. Res. Commun. 293 (3). United States: 1037–46. doi:10.1016/S0006-291X(02)00332-7. ISSN 0006-291X. PMID 12051764. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)