FEZF1

FEZF1
Identifiers
Aliases	FEZF1, FEZ, ZNF312B, HH22, FEZ family zinc finger 1
External IDs	OMIM: 613301; MGI: 1920441; HomoloGene: 19252; GeneCards: FEZF1; OMA:FEZF1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	122,310,691 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	23,248,361 bp
RNA expression pattern
	Top expressed in
	testicle; ; hypothalamus; ; caudate nucleus; ; amygdala; ; olfactory zone of nasal mucosa; ; putamen; ; left testis; ; nucleus accumbens; ; gonad; ; right testis;
	Top expressed in
	external naris; ; ventromedial nucleus; ; respiratory epithelium; ; olfactory epithelium; ; Jacobson's organ; ; lumbar spinal ganglion; ; zygote; ; suprachiasmatic nucleus; ; mesencephalon; ; lateral hypothalamus;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; metal ion binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; nucleic acid binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; cytosol;
Biological process	forebrain anterior/posterior pattern specification; cell differentiation; regulation of transcription, DNA-templated; neuron migration; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated; nervous system development; positive regulation of transcription, DNA-templated; multicellular organism development; telencephalon development; positive regulation of neuron differentiation; forebrain development; olfactory bulb development; negative regulation of cell population proliferation; axon guidance; cell dedifferentiation; regulation of neurogenesis;
	Sources:Amigo / QuickGO
Orthologs
	389549
	73191
	ENSG00000128610
	ENSMUSG00000029697
	A0PJY2
	Q0VDQ9
	NM_001024613; NM_001160264
	NM_028462
	NP_001019784; NP_001153736
	NP_082738
	Wikidata
View/Edit Human	View/Edit Mouse

FEZ family zinc finger 1 is a protein that in humans is encoded by the FEZF1 gene.^[5]

Clinical significance

Mutations in FEZF1 cause Template:SWL.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128610 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029697 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: FEZ family zinc finger 1".
^ Kotan LD, Hutchins BI, Ozkan Y, Demirel F, Stoner H, Cheng PJ, Esen I, Gurbuz F, Bicakci YK, Mengen E, Yuksel B, Wray S, Topaloglu AK (September 2014). "Mutations in FEZF1 cause Kallmann syndrome". American Journal of Human Genetics. 95 (3): 326–31. doi:10.1016/j.ajhg.2014.08.006. PMC 4157145. PMID 25192046.

Song IS, Oh NS, Kim HT, Ha GH, Jeong SY, Kim JM, Kim DI, Yoo HS, Kim CH, Kim NS (April 2009). "Human ZNF312b promotes the progression of gastric cancer by transcriptional activation of the K-ras gene". Cancer Research. 69 (7): 3131–9. doi:10.1158/0008-5472.CAN-08-2240. PMID 19318583.
Ulrich M, Seeber S, Becker CM, Enz R (January 2007). "Tax1-binding protein 1 is expressed in the retina and interacts with the GABA(C) receptor rho1 subunit". The Biochemical Journal. 401 (2): 429–36. doi:10.1042/BJ20061036. PMC 1820818. PMID 16999686.
Maestrini E, Pagnamenta AT, Lamb JA, Bacchelli E, Sykes NH, Sousa I, Toma C, Barnby G, Butler H, Winchester L, Scerri TS, Minopoli F, Reichert J, Cai G, Buxbaum JD, Korvatska O, Schellenberg GD, Dawson G, de Bildt A, Minderaa RB, Mulder EJ, Morris AP, Bailey AJ, Monaco AP (September 2010). "High-density SNP association study and copy number variation analysis of the AUTS1 and AUTS5 loci implicate the IMMP2L-DOCK4 gene region in autism susceptibility". Molecular Psychiatry. 15 (9): 954–68. doi:10.1038/mp.2009.34. PMC 2934739. PMID 19401682.
Song IS, Ha GH, Kim JM, Jeong SY, Lee HC, Kim YS, Kim YJ, Kwon TK, Kim NS (November 2011). "Human ZNF312b oncogene is regulated by Sp1 binding to its promoter region through DNA demethylation and histone acetylation in gastric cancer". International Journal of Cancer. 129 (9): 2124–33. doi:10.1002/ijc.25871. PMID 21170990.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000128610 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029697 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FEZ family zinc finger 1".

[6] Kotan LD, Hutchins BI, Ozkan Y, Demirel F, Stoner H, Cheng PJ, Esen I, Gurbuz F, Bicakci YK, Mengen E, Yuksel B, Wray S, Topaloglu AK (September 2014). "Mutations in FEZF1 cause Kallmann syndrome". American Journal of Human Genetics. 95 (3): 326–31. doi:10.1016/j.ajhg.2014.08.006. PMC 4157145. PMID 25192046.

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Clinical significance

References

Further reading