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FPGT

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FPGT
Identifiers
AliasesFPGT, GFPP, fucose-1-phosphate guanylyltransferase
External IDsOMIM: 603609; MGI: 1922790; HomoloGene: 2847; GeneCards: FPGT; OMA:FPGT - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003838
NM_001199328
NM_001199329

NM_029330

RefSeq (protein)

NP_001186257
NP_001186258
NP_003829

NP_083606

Location (UCSC)Chr 1: 74.2 – 74.23 MbChr 3: 154.79 – 154.8 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Fucose-1-phosphate guanylyltransferase is an enzyme that in humans is encoded by the FPGT gene.[5][6]

L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell–cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose.

There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids.

This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose.[6]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000254685Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053870Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Pastuszak I, Ketchum C, Hermanson G, Sjoberg EJ, Drake R, Elbein AD (Dec 1998). "GDP-L-fucose pyrophosphorylase. Purification, cDNA cloning, and properties of the enzyme". J Biol Chem. 273 (46): 30165–74. doi:10.1074/jbc.273.46.30165. PMID 9804772.
  6. ^ a b "Entrez Gene: FPGT fucose-1-phosphate guanylyltransferase".

Further reading

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