FXYD1

FXYD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2JO1
Identifiers
Aliases	FXYD1, PLM, FXYD domain containing ion transport regulator 1
External IDs	OMIM: 602359; MGI: 1889273; HomoloGene: 3691; GeneCards: FXYD1; OMA:FXYD1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	35,143,109 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	30,756,624 bp
RNA expression pattern
	Top expressed in
	muscle of thigh; ; apex of heart; ; tibial nerve; ; gastrocnemius muscle; ; skeletal muscle tissue; ; right coronary artery; ; right auricle; ; left ventricle; ; putamen; ; popliteal artery;
	Top expressed in
	muscle of thigh; ; choroid plexus of fourth ventricle; ; ankle; ; triceps brachii muscle; ; temporal muscle; ; right ventricle; ; digastric muscle; ; interventricular septum; ; sternocleidomastoid muscle; ; soleus muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sodium channel regulator activity; transmembrane transporter binding; ion channel activity; chloride channel activity; ion channel regulator activity;
Cellular component	integral component of membrane; membrane; integral component of plasma membrane; sodium:potassium-exchanging ATPase complex; sarcolemma; T-tubule; intercalated disc; plasma membrane; caveola; apical plasma membrane;
Biological process	muscle contraction; regulation of heart contraction; positive regulation of sodium ion export across plasma membrane; ion transport; regulation of sodium ion transmembrane transporter activity; regulation of cardiac muscle cell membrane potential; chloride transmembrane transport; negative regulation of protein glutathionylation; potassium ion transport; sodium ion transport; chloride transport; ion transmembrane transport; regulation of ion transport; regulation of cardiac conduction;
	Sources:Amigo / QuickGO
Orthologs
	5348
	56188
	ENSG00000266964
	ENSMUSG00000036570
	O00168
	Q9Z239
	NM_021902; NM_001278717; NM_001278718; NM_005031
	NM_019503; NM_052991; NM_052992; NM_194321
	NP_001265646; NP_001265647; NP_005022; NP_068702
	NP_062376; NP_443717; NP_443718; NP_919302
	Wikidata
View/Edit Human	View/Edit Mouse

Phospholemman (PLM) is a protein that in humans is encoded by the FXYD1 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000266964 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036570 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Chen LS, Lo CF, Numann R, Cuddy M (Jul 1997). "Characterization of the human and rat phospholemman (PLM) cDNAs and localization of the human PLM gene to chromosome 19q13.1". Genomics. 41 (3): 435–43. doi:10.1006/geno.1997.4665. PMID 9169143.
^ "Entrez Gene: FXYD1 FXYD domain containing ion transport regulator 1 (phospholemman)".

References

Further reading