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Flight 253 may refer to:
- Linea Aeropostal Venezolana Flight 253 (June 1956), an airliner that crashed in the Atlantic Ocean off New Jersey on 20 June 1956
- Linea Aeropostal Venezolana Flight 253 (November 1956), an airliner that crashed in Venezuela on 27 November 1956
- Seaboard World Airlines Flight 253A, Soviet-American airspace incident of 1 July 1968
- El Al Flight 253, attacked by terrorists while departing from a layover in Athens, Greece on 26 December 1968
- Northwest Airlines Flight 253, attempted terrorist bombing incident of 25 December 2009
| disambiguation page lists articles associated with the title Flight 253.
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