The group is based upon the website FlyLady.net, as well as a Constant Contact group for its email mailing list. Members of FlyLady have stated that the group has helped them and has changed their lives. 
FlyLady's messages cover topics include clutter, the value of routines, weekly and monthly cleaning, increased self-esteem, and letting go of perfectionism. As of 2016, she had over 300,000 subscribers on her email list, and 550,000 followers on Facebook. A store on her website sells organizational tools and housewares, sent from the FlyLady Distribution Center in Brevard, NC. In 2007, sales from the store reached US$4 million.
In November 2015 Alex Elsea, Marla's nephew, launched FlyLady Premium, a paid virtual mentoring service which adds extra support to followers of the FlyLady methodology in small private online groups. FlyLady Premium released an app, FlyLadyPlus in July 2016. Later in 2016, FlyLady herself released a subscription-based iOS reminder app, FlyLady Messenger.
Marla Cilley, founder of FlyLady, is from North Carolina. In 1999, Cilley joined a web forum called SHE's Online, based on the housekeeping system created by Pam Young and Peggy Jones, ("The Slob Sisters") detailed in their book Sidetracked Home Executives: From Pigpen to Paradise (1977)
The book covers many of the key topics that were adapted to become the FlyLady system; daily task lists, routines, "slipshod cleaning", and a systematic view to housekeeping. Marla Cilley refers to Pam and Peggy as her mentors and inspiration. She licensed the "Sidetracked Home Executives" system, and the Flylady system is based upon it.
The name FlyLady was Marla Cilley's screen name, as she was a fly-fishing fan and instructor. One of the members of the FlyLady e-mail list later created a "backronym" for FLY: Finally Loving Yourself.
FlyLady's methodology is outlined in Cilley's book Sink Reflections (Bantam Books, ISBN 0-553-38217-9) and on the web site. The system encourages "baby steps" to develop routines and habits to organize and maintain your home. The primary focus is on "Finally Loving Yourself" by making your life easier by decluttering, menu planning, "anti-procrastination" day, and establishing routines, as well as financial and health-related self-care
In 2007, Marla Cilley and co-author Leanne Ely also released a New York Times bestselling book called Body Clutter: Love Your Body, Love Yourself, which aims to apply the FlyLady's housekeeping methodology to caring for the reader's body, through self-examination and increased self-respect.
Key points in the FlyLady system include:
- Babysteps and Routines
- New recruits to the FlyLady system are called "Flybabies" and are introduced to "babysteps" - a series of 31 small daily tasks which introduce and then reinforce aspects of cleaning and decluttering, building up to creating personalized routines for morning, afternoon and evening. Once these routines are established, the "Flybaby" has "graduated" and will no longer need the scaffolding of the emails.
- Shine Your Sink
- Cilley's first instruction to new members is "Go shine your sink!" She asserts that even in a messy kitchen, the cleaned-out and polished sink provides positive reinforcement to the person who cleaned it, encouraging further cleaning in the rest of the room and home.
- 15 Minutes at a Time
- Cilley recommends using a timer to work for only 15 minutes at a time. The short time commitment helps stop procrastination, and reduces opportunities to get sidetracked or bored.
- Clutter Cannot Be Organized
- Cilley recommends that her followers get rid of excess items in their homes, and bring in fewer items, rather than attempting to organize them. This reduction "decluttering" is done 15 minutes at a time. One such exercise is FlyLady's "27-fling Boogie," in which the follower quickly selects 27 items in their home to discard and 27 items to give away.
- Weekly Routines
- Cilley advises the use of weekly routines, whereby each weekday is assigned an additional task or focus; Monday is daily cleaning, Wednesday is errand day, Thursday is grocery day and Friday is "desk day", focusing on paperwork and finances, as well as the day to declutter the car.
- Weekly Home Blessing
- Cilley's adaption of the Pam Young and Peggy Jones' "Slipshod cleaning" is the one-hour housecleaning mission called the "weekly home blessing." Using their timers, followers are instructed to vacuum, dust, mop, empty trash, change bedsheets and clean up old magazines. Each task is allocated ten minutes only.
- Get Dressed to Shoes
- Cilley insists that her followers "get dressed to lace-up shoes" before beginning their housekeeping tasks - or contacting her for an interview.
- Flylady divides a house into five sections or zones, which are allocated to the five weeks or partial weeks of the month. Each day the email list will provide a "mission" with a detailed cleaning task in the current zone.
- Control Journal
- Flylady advises the use of a "Control Journal," a household management notebook or binder, to store the owner's routines, lists and other important household information.
- Flylady Reminders
- Daily reminders of the routines, zones and missions, as well as "testimonials" of the system and products, are sent to subscribers of the FlyLady list.
- Perfectionism leads to Procrastination
- FlyLady asserts that the most frequent reason for procrastination and inefficiency is perfectionism, as people won't start a task if they think they don't have the time or the ability to do it perfectly. Some frequently repeated sayings in this respect are "good enough is good enough" or "housework done incorrectly still blesses your family".
- No Whining
- FlyLady often repeats that her Facebook page is a "No Whining Zone", and that "If you can't say anything nice, say nothing at all".
- Molly Millett (2003-02-22). "To bust clutter, who you gonna call? FlyLady!". Lifestyle. St. Louis Post-Dispatch. p. 10. Retrieved 2007-07-21.
- Getting Rid of Email Stress!
- Mary Beth Breckenridge (2003-04-27). "FlyLady helps you put house in order". The Miami Herald. p. 20H. Retrieved 2007-07-21.
- Aman Batheja (2005-01-02). "FlyLady fans log into domestic support group". San Diego Union-Tribune. Retrieved 2007-07-21.
- "Interview with Marla Cilley aka FlyLady - Nixon Virtual Strategies". Nixon Virtual Strategies. 2016-09-19. Retrieved 2016-11-21.
- Susan Hauser (2007-08-16). "How FlyLady nags her way to millions". Fortune Small Business. Retrieved 2011-05-06.
- "Duke Student's Startup Refreshes 17-Year-Old Home Organizing Guru FlyLady". ExitEvent. Retrieved 2016-11-21.
- "FlyLadyPlus on the App Store". App Store. Retrieved 2016-11-21.
- "FlyLady Messenger on the App Store". App Store. Retrieved 2016-11-21.
- Deirdre Donahue (2002-09-30). "FlyLady says a tidy soul comes first". USA Today. Retrieved 2007-07-21.
- Young, Pam; Peggy Jones (January 1977). Sidetracked home executives: From pigpen to paradise. Binford & Mort. ASIN B000H590VI.
- Elizabeth Lund (2002-07-10). "When domestic chaos threatens, FlyLady buzzes to the rescue". The Christian Science Monitor. Archived from the original on 2011-05-16. Retrieved 2007-07-21.
- Molly Millett (2006-04-22). "FlyLady devotees find peace through cleaner homes, organization and mother wit". St. Paul Pioneer Press. p. J1. Retrieved 2007-07-21.
- Cilley, Marla; Leanne Ely (January 2007). Body Clutter: Love Your Body, Love Yourself. Fireside. ISBN 978-1-4165-3462-4.
- Kate Beem (2010-03-30). "The FlyLady helps you (and thousands of others) reel in spring cleaning". Deseret News. Retrieved 2011-05-05.