Francisco Pellicer was born in the parish of Leon in Menorca around 1747 to Antonio Pellicer and Juana Sintes. At approximately 21, he came to New Smyrna, Florida as a member of Andrew Turnbull's colony. He married Margarita Femanias and they had two children in the colony and two more in St. Augustine. He bought a lot on Saint George Street with Jose Peso de Burgo and they built a duplex house. Pellicer did well as one of a dozen carpenters in the colony and later bought land on present-day Orange Street.
His Great Floridian plaque is located at the Pellicer-DeBurgo House (reconstructed) at 53 Saint George Street in St. Augustine, which is used as a British style pub in the Colonial Quarter museum complex.