Frank W. Crowe

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Frank Wilkinson Crowe (July 2, 1919 – April 29, 1987) was an American physician, who practiced Dermatology in Boise, Idaho and was a world-renowned authority for the Crowe sign or Crowe's sign in neurofibromatosis.

In 1956 Crowe et al. recognised the autosomal dominant heredity of neurofibromatosis and the use of 6 or more café au lait spots to diagnose the condition.[1] In 1964 Crowe published work on the use of axillary freckling in its diagnosis, which is now referred to as the Crowe sign.[2]


  1. ^ Frank W. Crowe, William J. Schull, James V. Neel. Multiple Neurofibromatosis. Charles C Thomas, Publisher, 301–327 E. Lawrence Ave., Springfield, Ill., 1956.
  2. ^ Crowe FW (December 1964). "Axillary Freckling as a Diagnostic Aid in Neurofibromatosis". Ann. Intern. Med. 61: 1142–3. doi:10.7326/0003-4819-61-6-1142. PMID 14233837. 

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