G3BP1

G3BP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3Q90, 4FCJ, 4FCM, 4IIA
Identifiers
Aliases	G3BP1, G3BP, HDH-VIII, G3BP stress granule assembly factor 1
External IDs	OMIM: 608431; MGI: 1351465; HomoloGene: 38096; GeneCards: G3BP1; OMA:G3BP1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	151,812,911 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	55,395,664 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; epithelium of colon; ; ganglionic eminence; ; gonad; ; islet of Langerhans; ; stromal cell of endometrium; ; Achilles tendon; ; tonsil; ; muscle of thigh; ; gastrocnemius muscle;
	Top expressed in
	Ileal epithelium; ; ventricular zone; ; corneal stroma; ; lactiferous gland; ; embryo; ; embryo; ; tail of embryo; ; plantaris muscle; ; epiblast; ; extensor digitorum longus muscle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; nucleotide binding; helicase activity; DNA helicase activity; protein binding; nucleic acid binding; nuclease activity; endonuclease activity; ATP binding; hydrolase activity; mRNA binding; RNA binding;
Cellular component	membrane; focal adhesion; plasma membrane; intracellular anatomical structure; cytoplasmic stress granule; nucleus; cytoplasm; cytosol; perikaryon; ribonucleoprotein complex;
Biological process	nucleic acid phosphodiester bond hydrolysis; Ras protein signal transduction; negative regulation of canonical Wnt signaling pathway; DNA duplex unwinding; transport; stress granule assembly;
	Sources:Amigo / QuickGO
Orthologs
	10146
	27041
	ENSG00000145907
	ENSMUSG00000018583
	Q13283
	P97855
	NM_005754; NM_198395
	NM_013716
	NP_005745; NP_938405
	NP_038744
	Wikidata
View/Edit Human	View/Edit Mouse

Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene.^[5]^[6]^[7]

Template:PBB Summary

Interactions

G3BP1 has been shown to interact with USP10.^[8] It also interacts with SND1[5].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145907 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018583 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Parker F, Maurier F, Delumeau I, Duchesne M, Faucher D, Debussche L, Dugue A, Schweighoffer F, Tocque B (Jul 1996). "A Ras-GTPase-activating protein SH3-domain-binding protein". Mol Cell Biol. 16 (6): 2561–9. PMC 231246. PMID 8649363.
^ Costa M, Ochem A, Staub A, Falaschi A (Mar 1999). "Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway". Nucleic Acids Res. 27 (3): 817–21. doi:10.1093/nar/27.3.817. PMC 148252. PMID 9889278.
^ "Entrez Gene: G3BP1 GTPase activating protein (SH3 domain) binding protein 1".
^ Soncini, C; Berdo I; Draetta G (Jun 2001). "Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease". Oncogene. 20 (29). England: 3869–79. doi:10.1038/sj.onc.1204553. ISSN 0950-9232. PMID 11439350. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)

[5]Gao X, Ge L, Shao J, Su C, Zhao H, Saarikettu J, Yao X, Yao Z, Silvennoinen O, Yang J., Tudor-SN interacts with and co-localizes with G3BP in stress granules under stress conditions.FEBS Letters, Volume 584, Issue 16, Pages 3525-3532.

External links

G3BP1 human gene location in the UCSC Genome Browser.
G3BP1 human gene details in the UCSC Genome Browser.

Template:PBB Controls

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145907 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018583 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8649363-5] Parker F, Maurier F, Delumeau I, Duchesne M, Faucher D, Debussche L, Dugue A, Schweighoffer F, Tocque B (Jul 1996). "A Ras-GTPase-activating protein SH3-domain-binding protein". Mol Cell Biol. 16 (6): 2561–9. PMC 231246. PMID 8649363.

[pmid9889278-6] Costa M, Ochem A, Staub A, Falaschi A (Mar 1999). "Human DNA helicase VIII: a DNA and RNA helicase corresponding to the G3BP protein, an element of the ras transduction pathway". Nucleic Acids Res. 27 (3): 817–21. doi:10.1093/nar/27.3.817. PMC 148252. PMID 9889278.

[entrez-7] "Entrez Gene: G3BP1 GTPase activating protein (SH3 domain) binding protein 1".

[pmid11439350-8] Soncini, C; Berdo I; Draetta G (Jun 2001). "Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease". Oncogene. 20 (29). England: 3869–79. doi:10.1038/sj.onc.1204553. ISSN 0950-9232. PMID 11439350. {{cite journal}}: Cite has empty unknown parameters: |laysummary=, |laydate=, and |laysource= (help)

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Interactions

References

Further reading

External links