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Guanine nucleotide binding protein-like 3 (nucleolar)
Symbols GNL3 ; C77032; E2IG3; NNP47; NS
External IDs OMIM608011 MGI1353651 HomoloGene56670 GeneCards: GNL3 Gene
RNA expression pattern
PBB GE GNL3 217850 at tn.png
More reference expression data
Species Human Mouse
Entrez 26354 30877
Ensembl ENSG00000163938 ENSMUSG00000042354
UniProt Q9BVP2 Q8CI11
RefSeq (mRNA) NM_014366 NM_153547
RefSeq (protein) NP_055181 NP_705775
Location (UCSC) Chr 3:
52.68 – 52.69 Mb
Chr 14:
31.01 – 31.02 Mb
PubMed search [1] [2]

Guanine nucleotide-binding protein-like 3, also known as nucleostemin, is a protein that in humans is encoded by the GNL3 gene.[1][2][3] It is found within the nucleolus that binds p53.[4] Nucleostemin regulates the cell cycle and affects cell differentiation, decreasing in amount as this differentiation progresses.[4] It is a marker for many stem cells and cancer cells.[5]


GNL3 has been shown to interact with Mdm2[6] and P53.[2]


  1. ^ Charpentier AH, Bednarek AK, Daniel RL, Hawkins KA, Laflin KJ, Gaddis S, MacLeod MC, Aldaz CM (Nov 2000). "Effects of estrogen on global gene expression: identification of novel targets of estrogen action". Cancer Res. 60 (21): 5977–83. PMID 11085516. 
  2. ^ a b Tsai RY, McKay RD (Dec 2002). "A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells". Genes Dev. 16 (23): 2991–3003. doi:10.1101/gad.55671. PMC 187487. PMID 12464630. 
  3. ^ "Entrez Gene: GNL3 guanine nucleotide binding protein-like 3 (nucleolar)". 
  4. ^ a b Ross, Michael H.; Pawlina, Wojciech. (2011). Histology : a text and atlas : with correlated cell and molecular biolog. Philadelphia: Wolters Kluwer/Lippincott Williams Wilkins Health. p. 79. ISBN 0-7817-7200-1. 
  5. ^ Niall M. Adams (29 November 2010). Advances in Nuclear Architecture. Springer. p. 31. ISBN 978-90-481-9898-6. Retrieved 27 September 2011. 
  6. ^ Dai MS, Sun XX, Lu H (Jul 2008). "Aberrant expression of nucleostemin activates p53 and induces cell cycle arrest via inhibition of MDM2". Mol. Cell. Biol. 28 (13): 4365–76. doi:10.1128/MCB.01662-07. PMC 2447154. PMID 18426907. 

Further reading[edit]