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Glypican 4

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GPC4
Identifiers
AliasesGPC4, K-glypican, glypican 4, KPTS
External IDsOMIM: 300168; MGI: 104902; HomoloGene: 55582; GeneCards: GPC4; OMA:GPC4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001448

NM_008150

RefSeq (protein)

NP_001439

NP_032176

Location (UCSC)Chr X: 133.3 – 133.42 MbChr X: 51.14 – 51.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glypican-4 is a protein that in humans is encoded by the GPC4 gene.[5][6]

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.[6]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000076716Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031119Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Veugelers M, Vermeesch J, Watanabe K, Yamaguchi Y, Marynen P, David G (October 1998). "GPC4, the gene for human K-glypican, flanks GPC3 on xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome". Genomics. 53 (1): 1–11. doi:10.1006/geno.1998.5465. PMID 9787072.
  6. ^ a b "Entrez Gene: GPC4 glypican 4".

Further reading

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