Glypican 4

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GPC4
Identifiers
AliasesGPC4, K-glypican, glypican 4, KPTS
External IDsOMIM: 300168 MGI: 104902 HomoloGene: 55582 GeneCards: GPC4
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for GPC4
Genomic location for GPC4
BandXq26.2Start133,300,103 bp[1]
End133,415,489 bp[1]
RNA expression pattern
PBB GE GPC4 204984 at fs.png

PBB GE GPC4 204983 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001448

NM_008150

RefSeq (protein)

NP_001439

NP_032176

Location (UCSC)Chr X: 133.3 – 133.42 MbChr X: 52.05 – 52.17 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glypican-4 is a protein that in humans is encoded by the GPC4 gene.[5][6]

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.[6]

See also[edit]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000076716 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031119 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Veugelers M, Vermeesch J, Watanabe K, Yamaguchi Y, Marynen P, David G (October 1998). "GPC4, the gene for human K-glypican, flanks GPC3 on xq26: deletion of the GPC3-GPC4 gene cluster in one family with Simpson-Golabi-Behmel syndrome". Genomics. 53 (1): 1–11. doi:10.1006/geno.1998.5465. PMID 9787072.
  6. ^ a b "Entrez Gene: GPC4 glypican 4".

Further reading[edit]

External links[edit]