Geroprotector

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A geroprotector is a senotherapeutic that aims to affect the root cause of aging and age-related diseases, and thus prolong the life span of animals.[1][2][3] Some possible geroprotectors include melatonin,[4] carnosine,[5] metformin[6] and delta sleep-inducing peptide.[7]

References[edit]

  1. ^ De-novo geroprotector design, SENS Foundation
  2. ^ Alexey Moskalev, Elizaveta Chernyagina, Anna Kudryavtseva & Mikhail Shaposhnikov (2017). "Geroprotectors: A Unified Concept and Screening Approaches". Aging and disease. 8 (3): 354–363. doi:10.14336/AD.2016.1022. PMC 5440114Freely accessible. PMID 28580190. 
  3. ^ Alexey Moskalev, Elizaveta Chernyagina, Joao Pedro de Magalhaes & Alex Zhavoronkov (2015). "Geroprotectors.org: a new, structured and curated database of current therapeutic interventions in aging and age-related disease". Aging. 7 (9): 616–628. doi:10.18632/aging.100799. PMC 4600621Freely accessible. PMID 26342919. 
  4. ^ Anisimov, VN; Popovich, IG; Zabezhinski, MA; Anisimov, SV; Vesnushkin, GM; Vinogradova, IA (2006). "Melatonin as antioxidant, geroprotector and anticarcinogen". Biochimica et Biophysica Acta. 1757 (5–6): 573–89. doi:10.1016/j.bbabio.2006.03.012. PMID 16678784. 
  5. ^ Boldyrev, AA; Stvolinsky, SL; Fedorova, TN; Suslina, ZA (2010). "Carnosine as a natural antioxidant and geroprotector: From molecular mechanisms to clinical trials". Rejuvenation research. 13 (2–3): 156–8. doi:10.1089/rej.2009.0923. PMID 20017611. 
  6. ^ Bulterijs, S (2011). "Metformin As a Geroprotector". Rejuvenation research. 14 (5): 469–82. doi:10.1089/rej.2011.1153. PMID 21882902. 
  7. ^ Bondarenko, TI (2011). "Mechanism of delta-sleep inducing peptide geroprotective activity". Adv Gerontol. 24 (1): 80–92. PMID 21809625. 

External links[edit]

  • Geroprotectors: A curated database of geroprotectors.
  • Aging Chart: A collection of community-curated pathways and knowledge related to aging.