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H6PD

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H6PD
Identifiers
AliasesH6PD, CORTRD1, G6PDH, GDH, hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase, H6PDH
External IDsOMIM: 138090; MGI: 2140356; HomoloGene: 48275; GeneCards: H6PD; OMA:H6PD - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001282587
NM_004285

NM_001291004
NM_173371

RefSeq (protein)

NP_001269516
NP_004276

NP_001277933
NP_775547

Location (UCSC)Chr 1: 9.23 – 9.27 MbChr 4: 150.06 – 150.09 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GDH/6PGL endoplasmic bifunctional protein is a protein that in humans is encoded by the H6PD gene.[5][6]

Function

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There are two forms of glucose-6-phosphate dehydrogenase. G form is X-linked and H form, encoded by this gene, is autosomally linked. This H form shows activity with other hexose-6-phosphates, especially galactose-6-phosphate, whereas the G form is specific for glucose-6-phosphate. Both forms are present in most tissues, but H form is not found in red cells.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000049239Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028980Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mason PJ, Stevens D, Diez A, Knight SW, Scopes DA, Vulliamy TJ (Jul 1999). "Human hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) encoded at 1p36: coding sequence and expression". Blood Cells Mol Dis. 25 (1): 30–7. doi:10.1006/bcmd.1999.0224. PMID 10349511.
  6. ^ a b "Entrez Gene: H6PD hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)".

Further reading

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