HARS2

HARS2
Identifiers
Aliases	HARS2, HARSL, HARSR, HO3, PRLTS2, histidyl-tRNA synthetase 2, mitochondrial, HisRS
External IDs	OMIM: 600783; MGI: 1918041; HomoloGene: 40819; GeneCards: HARS2; OMA:HARS2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	140,699,305 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	36,925,615 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; apex of heart; ; granulocyte; ; mucosa of transverse colon; ; right adrenal cortex; ; rectum; ; right uterine tube; ; body of uterus; ; right ovary;
	Top expressed in
	neural layer of retina; ; ventricular zone; ; spermatocyte; ; superior frontal gyrus; ; right kidney; ; primary visual cortex; ; granulocyte; ; thymus; ; proximal tubule; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	aminoacyl-tRNA ligase activity; nucleotide binding; ligase activity; protein binding; ATP binding; protein homodimerization activity; histidine-tRNA ligase activity; RNA binding; identical protein binding;
Cellular component	cytoplasm; mitochondrial matrix; mitochondrion; cytosol;
Biological process	protein biosynthesis; histidyl-tRNA aminoacylation; mitochondrial translation; tRNA aminoacylation for protein translation;
	Sources:Amigo / QuickGO
Orthologs
	23438
	70791
	ENSG00000112855
	ENSMUSG00000019143
	P49590
	Q99KK9
	NM_001278731; NM_001278732; NM_012208; NM_001363535; NM_001363536
	NM_080636; NM_001305627; NM_001360921
	NP_001265660; NP_001265661; NP_036340; NP_001350464; NP_001350465
	NP_001292556; NP_542367; NP_001347850
	Wikidata
View/Edit Human	View/Edit Mouse

Probable histidyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the HARS2 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112855 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019143 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ O'Hanlon TP, Raben N, Miller FW (Jun 1995). "A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA synthetase (HRS) gene encodes an mRNA that predicts a polypeptide homologous to HRS". Biochem Biophys Res Commun. 210 (2): 556–66. doi:10.1006/bbrc.1995.1696. PMID 7755634.
^ "Entrez Gene: HARS2 histidyl-tRNA synthetase 2, mitochondrial (putative)".

References

Further reading