HBV RNA encapsidation signal epsilon

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HBV RNA encapsidation signal epsilon
HBV Epsilon.jpg
Predicted secondary structure and sequence conservation of HBV_epsilon
Symbol HBV_epsilon
Alt. Symbols HBV
Rfam RF01047
Other data
RNA type Cis-reg
Domain(s) Viruses
GO 0019079
SO 0005836

The HBV RNA encapsidation signal epsilon (HBV_epsilon) is an element essential for HBV virus replication.

It is an RNA structure situated near the 5' end of the HBV pregenomic RNA.[1] The structure consists of a lower stem, a bulge region, an upper stem and a tri-loop. The structure was determined and refined through enzymatic probing and NMR spectroscopy.[2] The closure of the tri-loop was not predicted by RNA structure prediction programs but observed in the NMR structure. The regions shown to be critical for encapsidation of the RNA in the viral lifecycle are the bulge, upper stem and tri-loop which interact with the terminal protein domain of the HBV viral polymerase.[3][4]

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  1. ^ Beck J, Nassal M (January 2007). "Hepatitis B virus replication". World J. Gastroenterol. 13 (1): 48–64. PMC 4065876Freely accessible. PMID 17206754. doi:10.3748/wjg.v13.i1.48. 
  2. ^ Flodell S, Schleucher J, Cromsigt J, Ippel H, Kidd-Ljunggren K, Wijmenga S (November 2002). "The apical stem-loop of the hepatitis B virus encapsidation signal folds into a stable tri-loop with two underlying pyrimidine bulges". Nucleic Acids Res. 30 (21): 4803–4811. PMC 135823Freely accessible. PMID 12409471. doi:10.1093/nar/gkf603. 
  3. ^ Kramvis A, Kew MC (November 1998). "Structure and function of the encapsidation signal of hepadnaviridae". J. Viral Hepat. 5 (6): 357–367. PMID 9857345. doi:10.1046/j.1365-2893.1998.00124.x. 
  4. ^ Beck, J; Nassal, M (2003). "Efficient Hsp90-independent in vitro activation by Hsc70 and Hsp40 of duck hepatitis B virus reverse transcriptase, an assumed Hsp90 client protein.". The Journal of Biological Chemistry. 278 (38): 36128–38. PMID 12851401. doi:10.1074/jbc.M301069200. 

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