HIST1H1C

H1-2
Identifiers
Aliases	H1-2, H1.2, H1C, H1F2, H1s-1, histone cluster 1, H1c, histone cluster 1 H1 family member c, HIST1H1C, H1.2 linker histone, cluster member
External IDs	OMIM: 142710 MGI: 1931526 HomoloGene: 68455 GeneCards: H1-2
Gene location (Human) Chr. Chromosome 6 (human) Band 6p22.2 Start 26,055,740 bp End 26,056,470 bp
Gene location (Mouse) Chr. Chromosome 13 (mouse) Band 13|13 A3.1 Start 23,922,791 bp End 23,924,350 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon gastrocnemius muscle right uterine tube left ventricle right lobe of liver right lung prostate right adrenal gland islet of Langerhans right lobe of thyroid gland Top expressed in calvaria left colon ankle blood vastus lateralis muscle triceps brachii muscle seminal vesicula submandibular gland intercostal muscle digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding chromatin DNA binding protein binding RNA binding double-stranded DNA binding nucleosomal DNA binding Cellular component nucleosome nucleus chromosome Biological process regulation of transcription by RNA polymerase II histone H3-K4 trimethylation nucleosome assembly negative regulation of transcription by RNA polymerase II histone H3-K27 trimethylation regulation of transcription, DNA-templated chromosome condensation negative regulation of DNA recombination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3006 50708 Ensembl ENSG00000187837 ENSMUSG00000036181 UniProt P16403 P15864 RefSeq (mRNA) NM_005319 NM_015786 RefSeq (protein) NP_005310 NP_056601 Location (UCSC) Chr 6: 26.06 – 26.06 Mb Chr 13: 23.92 – 23.92 Mb PubMed search
Wikidata
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Histone H1.2 is a protein that in humans is encoded by the HIST1H1C gene.

Apart from its roles in the nucleus, histone H1.2 also participates in apoptosis. In response to apoptotic stimuli, mainly DNA damage, it is translocated from the nucleus to the cytosol. There, it activates Bak, a pro-apoptotic protein bound to the mithochondria outer membrane (MOM). Activation of Bak causes the perforation of the mitochondria, a process known as MOMP (mitochondria outer membrane permeabilization) which promotes apoptosis. Histone H1.2 also forms a complex with the apoptosome, possibly regulating its formation.