HOTAIR

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HOTAIR
Identifiers
Aliases HOTAIR, HOXAS, HOXC-AS4, HOXC11-AS1, NCRNA00072, HOX transcript antisense RNA
External IDs GeneCards: HOTAIR
Gene location (Human)
Chromosome 12 (human)
Chr. Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for HOTAIR
Genomic location for HOTAIR
Band 12q13.13 Start 53,962,308 bp[1]
End 53,974,956 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC) Chr 12: 53.96 – 53.97 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

HOTAIR (for HOX transcript antisense RNA)[3] is a human gene located on chromosome 12. It is the first example of an RNA expressed on one chromosome that has been found to influence transcription on another chromosome.

Gene and transcribed RNA product[edit]

The HOTAIR gene contains 6,232 bp and encodes 2.2 kb long noncoding RNA molecule, which controls gene expression. Its source DNA is located within a HOXC gene cluster. It is shuttled from chromosome 12 to chromosome 2 by the Suz-Twelve protein.[4]

Function[edit]

The 5' end of HOTAIR interacts with a Polycomb-group protein Polycomb Repressive Complex 2 (PRC2) and as a result regulates chromatin state. It is required for gene-silencing of the HOXD locus by PRC2.[5][6] The 3' end of HOTAIR interacts with the histone demethylase LSD1.[6]

It is an important factor in the epigenetic differentiation of skin over the surface of the body. Skin from various anatomical positions is distinct, e.g. the skin of the eyelid differs markedly from that on the sole of the foot.[5][7]

Clinical significance[edit]

HOTAIR is highly expressed in metastatic breast cancers. High levels of expression in primary breast tumours are a significant predictor of subsequent metastasis and death. In cells, especially those that over express PRC2, the prevention of HOTAIR expression leads to a reduction in invasive potential of that cell. [8] It is also involved in esophageal squamous cell carcinoma.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000228630 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ "Genecards entry on HOTAIR". Retrieved 20 July 2010. 
  4. ^ Petherick A (Aug 2008). "Genetics: The production line". Nature. 454 (7208): 1042–5. doi:10.1038/4541042a. PMID 18756228. 
  5. ^ a b Rinn JL, Kertesz M, Wang JK, Squazzo SL, Xu X, Brugmann SA, Goodnough LH, Helms JA, Farnham PJ, Segal E, Chang HY (Jun 2007). "Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs". Cell. 129 (7): 1311–23. doi:10.1016/j.cell.2007.05.022. PMC 2084369Freely accessible. PMID 17604720. 
  6. ^ a b Tsai MC, Manor O, Wan Y, Mosammaparast N, Wang JK, Lan F, Shi Y, Segal E, Chang HY (Aug 2010). "Long noncoding RNA as modular scaffold of histone modification complexes". Science. 329 (5992): 689–93. doi:10.1126/science.1192002. PMC 2967777Freely accessible. PMID 20616235. 
  7. ^ Chuong CM (Jan 2003). "Homeobox genes, fetal wound healing, and skin regional specificity". The Journal of Investigative Dermatology. 120 (1): 9–11. doi:10.1046/j.1523-1747.2003.00002.x. PMID 12535191. 
  8. ^ Gupta RA, Shah N, Wang KC, Kim J, Horlings HM, Wong DJ, Tsai MC, Hung T, Argani P, Rinn JL, Wang Y, Brzoska P, Kong B, Li R, West RB, van de Vijver MJ, Sukumar S, Chang HY (Apr 2010). "Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis". Nature. 464 (7291): 1071–6. doi:10.1038/nature08975. PMC 3049919Freely accessible. PMID 20393566. 
  9. ^ Chen FJ, Sun M, Li SQ, Wu QQ, Ji L, Liu ZL, Zhou GZ, Cao G, Jin L, Xie HW, Wang CM, Lv J, De W, Wu M, Cao XF (Nov 2013). "Upregulation of the long non-coding RNA HOTAIR promotes esophageal squamous cell carcinoma metastasis and poor prognosis". Molecular Carcinogenesis. 52 (11): 908–15. doi:10.1002/mc.21944. PMID 24151120. 

Further reading[edit]

External links[edit]