HOTAIR (for HOX transcript antisense RNA) is a human gene located on chromosome 12. It is the first example of an RNA expressed on one chromosome that has been found to influence transcription on another chromosome.
It is an important factor in the epigenetic differentiation of skin over the surface of the body. Skin from various anatomical positions is distinct, e.g. the skin of the eyelid differs markedly from that on the sole of the foot.
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Yang Z, Zhou L, Wu LM, Lai MC, Xie HY, Zhang F, Zheng SS (May 2011). "Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation". Annals of Surgical Oncology18 (5): 1243–50. doi:10.1245/s10434-011-1581-y. PMID21327457.
Nie Y, Liu X, Qu S, Song E, Zou H, Gong C (Apr 2013). "Long non-coding RNA HOTAIR is an independent prognostic marker for nasopharyngeal carcinoma progression and survival". Cancer Science104 (4): 458–64. doi:10.1111/cas.12092. PMID23281836.