Hippocalcin-like protein 1

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HPCAL1
Protein HPCAL1 PDB 1bjf.png
Identifiers
Aliases HPCAL1, BDR1, HLP2, VILIP-3, hippocalcin like 1
External IDs MGI: 1855689 HomoloGene: 37586 GeneCards: HPCAL1
RNA expression pattern
PBB GE HPCAL1 212552 at fs.png

PBB GE HPCAL1 205462 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001258357
NM_001258358
NM_001258359
NM_002149
NM_134421

NM_016677

RefSeq (protein)

NP_001245286
NP_001245287
NP_001245288
NP_002140
NP_602293

NP_057886.1
NP_057886

Location (UCSC) Chr 2: 10.3 – 10.43 Mb Chr 12: 17.69 – 17.79 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Hippocalcin-like protein 1 is a protein that in humans is encoded by the HPCAL1 gene.[3][4][5]

The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain.[6] It is highly similar to human hippocalcin protein and nearly identical to the rat and mouse hippocalcin like-1 proteins. It may be involved in the calcium-dependent regulation of rhodopsin phosphorylation and may be of relevance for neuronal signalling in the central nervous system. There are two alternatively spliced transcript variants of this gene, with multiple polyadenylation sites.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Kobayashi M, Takamatsu K, Fujishiro M, Saitoh S, Noguchi T (Aug 1994). "Molecular cloning of a novel calcium-binding protein structurally related to hippocalcin from human brain and chromosomal mapping of its gene". Biochim Biophys Acta. 1222 (3): 515–8. doi:10.1016/0167-4889(94)90062-0. PMID 8038222. 
  4. ^ Oikawa K, Kimura S, Aoki N, Atsuta Y, Takiyama Y, Nagato T, Yanai M, Kobayashi H, Sato K, Sasajima T, Tateno M (Apr 2004). "Neuronal calcium sensor protein visinin-like protein-3 interacts with microsomal cytochrome b5 in a Ca2+-dependent manner". J Biol Chem. 279 (15): 15142–52. doi:10.1074/jbc.M312766200. PMID 14739275. 
  5. ^ a b "Entrez Gene: HPCAL1 hippocalcin-like 1". 
  6. ^ Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812Freely accessible. PMID 17311005. 

Further reading[edit]