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AGFG1

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(Redirected from HRB (gene))

AGFG1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesAGFG1, HRB, RAB, RIP, ArfGAP with FG repeats 1
External IDsOMIM: 600862; MGI: 1333754; HomoloGene: 37929; GeneCards: AGFG1; OMA:AGFG1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001135187
NM_001135188
NM_001135189
NM_004504

NM_010472
NM_001310713
NM_001347077
NM_001368850

RefSeq (protein)

NP_001128659
NP_001128660
NP_001128661
NP_004495

NP_001297642
NP_001334006
NP_034602
NP_001355779

Location (UCSC)Chr 2: 227.47 – 227.56 MbChr 1: 82.82 – 82.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Arf-GAP domain and FG repeat-containing protein 1 is a protein that in humans is encoded by the AGFG1 gene.[5][6]

Function

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The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. This encoded protein binds the Rev activation domain when Rev is assembled onto its RNA target and can significantly enhance Rev activity when overexpressed. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[6]

Interactions

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AGFG1 has been shown to interact with EPS15L1[7] and EPS15.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000173744Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026159Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Fritz CC, Zapp ML, Green MR (September 1995). "A human nucleoporin-like protein that specifically interacts with HIV Rev". Nature. 376 (6540): 530–3. Bibcode:1995Natur.376..530F. doi:10.1038/376530a0. PMID 7637788. S2CID 4252707.
  6. ^ a b "Entrez Gene: HRB HIV-1 Rev binding protein".
  7. ^ a b Doria M, Salcini AE, Colombo E, Parslow TG, Pelicci PG, Di Fiore PP (December 1999). "The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport". J. Cell Biol. 147 (7): 1379–84. doi:10.1083/jcb.147.7.1379. PMC 2174238. PMID 10613896.

Further reading

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