HRB (gene)

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AGFG1
Protein HRB PDB 2d9l.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases AGFG1, HRB, RAB, RIP, ArfGAP with FG repeats 1
External IDs MGI: 1333754 HomoloGene: 37929 GeneCards: AGFG1
RNA expression pattern
PBB GE HRB 213926 s at fs.png

PBB GE HRB 218092 s at fs.png

PBB GE HRB 218091 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001135187
NM_001135188
NM_001135189
NM_004504

NM_010472
NM_001310713
NM_001347077

RefSeq (protein)

NP_001128659
NP_001128660
NP_001128661
NP_004495

NP_001297642.1
NP_034602.1
NP_001297642
NP_001334006
NP_034602

Location (UCSC) Chr 2: 227.47 – 227.56 Mb Chr 1: 82.84 – 82.9 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Arf-GAP domain and FG repeats-containing protein 1 is a protein that in humans is encoded by the AGFG1 gene.[3][4]

Function[edit]

The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. This encoded protein binds the Rev activation domain when Rev is assembled onto its RNA target and can significantly enhance Rev activity when overexpressed. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.[4]

Interactions[edit]

HRB (gene) has been shown to interact with EPS15L1[5] and EPS15.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Fritz CC, Zapp ML, Green MR (Sep 1995). "A human nucleoporin-like protein that specifically interacts with HIV Rev". Nature. 376 (6540): 530–3. doi:10.1038/376530a0. PMID 7637788. 
  4. ^ a b "Entrez Gene: HRB HIV-1 Rev binding protein". 
  5. ^ a b Doria M, Salcini AE, Colombo E, Parslow TG, Pelicci PG, Di Fiore PP (Dec 1999). "The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport". J. Cell Biol. 147 (7): 1379–84. doi:10.1083/jcb.147.7.1379. PMC 2174238Freely accessible. PMID 10613896. 

Further reading[edit]