HSD17B8

HSD17B8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2PD6, 4CQL, 4CQM
Identifiers
Aliases	HSD17B8, D6S2245E, FABG, FABGL, H2-KE6, HKE6, KE6, RING2, SDR30C1, dJ1033B10.9, hydroxysteroid (17-beta) dehydrogenase 8, hydroxysteroid 17-beta dehydrogenase 8
External IDs	OMIM: 601417; MGI: 95911; HomoloGene: 56588; GeneCards: HSD17B8; OMA:HSD17B8 - orthologs
EC number	1.1.1.239
Gene location (Human)
Chr.	Chromosome 6 (human)
End	33,206,831 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,247,034 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; right lobe of liver; ; right uterine tube; ; testicle; ; mucosa of transverse colon; ; right adrenal gland; ; human kidney; ; right adrenal cortex; ; left lobe of thyroid gland; ; right lobe of thyroid gland;
	Top expressed in
	adrenal gland; ; proximal tubule; ; right kidney; ; islet of Langerhans; ; human kidney; ; neural layer of retina; ; granulocyte; ; white adipose tissue; ; bone marrow; ; urinary bladder;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; estradiol 17-beta-dehydrogenase activity; protein binding; testosterone dehydrogenase (NAD+) activity; 3-hydroxyacyl-CoA dehydrogenase activity; 3-oxoacyl-[acyl-carrier-protein reductase (NADH) activity]; NADH binding; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor;
Cellular component	plasma membrane; mitochondrial envelope; membrane; mitochondrion; mitochondrial matrix;
Biological process	estrogen biosynthetic process; estrogen metabolic process; androgen metabolic process; fatty acid metabolic process; lipid metabolism; steroid biosynthetic process; fatty acid biosynthetic process; protein heterotetramerization; fatty-acyl-CoA biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	7923
	14979
ENSG00000204228; ENSG00000228357; ENSG00000225312; ENSG00000232357; ENSG00000112474;
	ENSG00000228712
	ENSMUSG00000073422
	Q92506
	P50171
	NM_014234
	NM_013543
	NP_055049
	NP_038571
	Wikidata
View/Edit Human	View/Edit Mouse

Estradiol 17 beta-dehydrogenase 8 is an enzyme that in humans is encoded by the HSD17B8 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c ENSG00000228357, ENSG00000225312, ENSG00000232357, ENSG00000112474, ENSG00000228712 GRCh38: Ensembl release 89: ENSG00000204228, ENSG00000228357, ENSG00000225312, ENSG00000232357, ENSG00000112474, ENSG00000228712 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000073422 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ando A, Kikuti YY, Shigenari A, Kawata H, Okamoto N, Shiina T, Chen L, Ikemura T, Abe K, Kimura M, Inoko H (Dec 1996). "cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region". Genomics. 35 (3): 600–2. doi:10.1006/geno.1996.0405. PMID 8812499.
^ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (Short-Chain Dehydrogenase/Reductase and Related Enzymes) Nomenclature Initiative". Chem Biol Interact. 178 (1–3): 94–8. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
^ Cite error: The named reference entrez was invoked but never defined (see the help page).

References

Further reading