- High Desert, Albuquerque, New Mexico, a development in Albuquerque, New Mexico, United States
- High Desert (California), an area encompassing north Los Angeles County, north San Bernardino County, and Kern County, California. The High Desert includes cities such as Lancaster, Lake Los Angeles, Hi Vista, Quartz Hill, Pearblossom, Littlerock, Sun Village, Adelanto, Palmdale, Barstow, Victorville and Apple Valley.
- High Desert (Oregon), an area in eastern Oregon, United States
- High Desert County, California, a proposed county in Southern California
- Colorado Plateau, a high desert area in the United States of 337,000 km2 (130,000 mi2) in western Colorado, northwestern New Mexico, southern and eastern Utah, and northern Arizona.
- The High Desert Museum in Bend, Oregon, United States
- High Desert State Prison (Nevada) in Indian Springs, Nevada
- High Desert State Prison (California) in Susanville, California
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