Hinsberg oxindole synthesis

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The Hinsberg oxindole synthesis is a method of preparing oxindoles from the bisulfite adducts of glyoxal.[1][2] It is named after its inventor Oscar Hinsberg.[3][4][5]

Hinsberg indole synthesis

See also[edit]


  1. ^ Elderfield, R.C. (1952). Heterocyclic Compounds. 3. New York. p. 139. 
  2. ^ Murthy, Sabbavarapu Narayana; Madhav, Bandaru; Nageswar, Yadavalli Venkata Durga (15 June 2010). "Revisiting the Hinsberg Reaction: Facile and Expeditious Synthesis of 3-Substituted Quinoxalin-2(1H)-ones under Catalyst-Free Conditions in Water". Helvetica Chimica Acta. 93 (6): 1216–1220. doi:10.1002/hlca.200900358. 
  3. ^ Hinsberg, O. (1888). "Ueber die Einwirkung der Natriumbisulfitverbindung des Glyoxals auf aromatische Monamine". Ber. Dtsch. Chem. Ges. 21: 110. doi:10.1002/cber.18880210122. 
  4. ^ Hinsberg, O.; Simeoff, A. (January 1898). "Synthese von Naphtindolderivaten". Berichte der deutschen chemischen Gesellschaft. 31 (1): 250–254. doi:10.1002/cber.18980310150. 
  5. ^ Hinsberg, O. (1908). "Über Glykokoll und Indol-derivate". Ber. Dtsch. Chem. Ges. 41: 1367. doi:10.1002/cber.190804101252.