Jackie Estacado discovers he is the father, having been used by the Darkness to conceive a baby while Sara was in a coma. The Darkness wished to create a new weapon with which to destroy its adversary, the Angelus. When the current Angelus host, Celestine, and her warriors attempt to take the unborn child by force, Jackie takes them to a mob safe house to hide. Patience also arrives, after Sara leaves her a message asking for help. Sara goes into labour and Dani acts as midwife while Jackie and Patience fend off a new assault by the Angelus. Hope's birth nearly kills Sara, but Dani heals her using the Witchblade and it is split between them. Celestine manages to grab hold of Hope, but the baby creates an explosion that destroys all the Angelus warriors and Celestine leaves in defeat.
A person known as the Survivor, revealed to have been the Curator, employs Aphrodite IV and gives her the Coin of Solomon in order to kidnap Hope as part of his plan to bring the Artifacts together. It is revealed that Hope is the "codex" for the entire universe, meaning that she has to die once all thirteen Artifacts are brought together so the Survivor's universe can be reborn. However, Jackie attacks the Survivor just as it happens. Jackie, Sara and Hope soon appear to be the only survivors as the universe fades to nothing. Realizing that Hope has to die for the sake of the world, Sara reluctantly chooses to kill her. When the universe is reset, it is revealed that Hope still lives, apparently the eight-year-old daughter of both Jackie and his ex-flame Jenny.
Hope created a burst of vast power shortly after her birth which severely weakened the Angelus and destroyed her warriors. Since then, she has not displayed anything unusual. As the Codex of the universe, her death can recreate entire worlds and reincarnate all souls, including her own.