Heterochromatin protein 1, binding protein 3 is a protein that in humans is encoded by the HP1BP3gene. It has been identified as a novel subtype of the linker histone H1, involved in the structure of heterochromatin 
HP1BP3 deficiency in mice results in severe dwarfism and impaired bone mass, caused by altered endocrine IGF-1 signaling. The gene is highly expressed in the brain and a number of behavioral phenotypes have been described for the mice. Lack of HP1BP3 led to impaired maternal behavior and reduced anxiety, leading to a dramatic reduction in litter survival. This may be related to the connection between HP1BP3 and postpartum depression in humans. Finally, HP1BP3 has been implicated in Alzheimer's disease..
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