ITGB1BP1

ITGB1BP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4DX8, 4DX9, 4JIF
Identifiers
Aliases	ITGB1BP1, ICAP-1A, ICAP-1B, ICAP-1alpha, ICAP1, ICAP1A, ICAP1B, integrin subunit beta 1 binding protein 1
External IDs	OMIM: 607153 MGI: 1306802 HomoloGene: 3496 GeneCards: ITGB1BP1
Gene location (Human) Chr. Chromosome 2 (human) Band 2p25.1 Start 9,403,475 bp End 9,423,528 bp
Gene location (Mouse) Chr. Chromosome 12 (mouse) Band 12|12 A1.3 Start 21,290,826 bp End 21,336,285 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in canal of the cervix subcutaneous adipose tissue abdominal fat tibial nerve caudate nucleus putamen gastric mucosa nucleus accumbens prefrontal cortex left coronary artery Top expressed in seminiferous tubule spermatid cerebellar cortex white adipose tissue cerebellar vermis morula nucleus accumbens olfactory tubercle superior frontal gyrus globus pallidus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function integrin binding kinase binding protein binding GDP-dissociation inhibitor activity protein kinase binding protein-containing complex binding Cellular component cytoplasm cytosol cell projection membrane focal adhesion ruffle plasma membrane perinuclear region of cytoplasm cytoskeleton nucleus lamellipodium cell periphery nucleoplasm microtubule organizing center nuclear body Biological process Notch signaling pathway positive regulation of protein targeting to membrane cell differentiation activation of protein kinase B activity myoblast migration negative regulation of fibroblast migration regulation of cell adhesion mediated by integrin intracellular signal transduction positive regulation of protein kinase B signaling regulation of transcription, DNA-templated negative regulation of protein kinase activity regulation of GTPase activity biomineral tissue development negative regulation of protein binding cellular response to fibroblast growth factor stimulus receptor clustering blood vessel endothelial cell proliferation involved in sprouting angiogenesis transcription, DNA-templated positive regulation of endothelial cell migration negative regulation of cell adhesion involved in substrate-bound cell migration negative regulation of cell migration involved in sprouting angiogenesis negative regulation of protein targeting to membrane tube formation regulation of integrin-mediated signaling pathway cell adhesion angiogenesis positive regulation of cell population proliferation protein transport integrin-mediated signaling pathway negative regulation of ERK1 and ERK2 cascade positive regulation of focal adhesion assembly cellular response to vascular endothelial growth factor stimulus integrin activation cell-matrix adhesion negative regulation of substrate adhesion-dependent cell spreading cell migration negative regulation of focal adhesion assembly positive regulation of cell division positive regulation of stress fiber assembly positive regulation of Notch signaling pathway negative regulation of cell population proliferation positive regulation of transcription by RNA polymerase II protein localization to plasma membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9270 16413 Ensembl ENSG00000119185 ENSMUSG00000062352 UniProt O14713 O35671 RefSeq (mRNA) NM_004763 NM_022334 NM_001319066 NM_001319067 NM_001319068 NM_001319069 NM_001319070 NM_001369744 NM_001369745 NM_001369746 NM_001369747 NM_001369748 NM_001369749 NM_001369750 NM_008403 NM_001355609 RefSeq (protein) NP_001305995 NP_001305996 NP_001305997 NP_001305998 NP_001305999 NP_004754 NP_071729 NP_001356673 NP_001356674 NP_001356675 NP_001356676 NP_001356677 NP_001356678 NP_001356679 NP_032429 NP_001342538 Location (UCSC) Chr 2: 9.4 – 9.42 Mb Chr 12: 21.29 – 21.34 Mb PubMed search
Wikidata
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Integrin beta-1-binding protein 1 is a protein that in humans is encoded by the ITGB1BP1 gene.

Interactions

ITGB1BP1 has been shown to interact with KRIT1, LRP2, CD29 and LRP1.