Intersectin 2

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ITSN2
Protein ITSN2 PDB 1j3t.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ITSN2, PRO2015, SH3D1B, SH3P18, SWA, SWAP, intersectin 2
External IDs MGI: 1338049 HomoloGene: 22627 GeneCards: ITSN2
RNA expression pattern
PBB GE ITSN2 209907 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_147152
NM_006277
NM_019595

NM_001198968
NM_001198969
NM_011365

RefSeq (protein)

n/a

Location (UCSC) Chr 2: 24.2 – 24.36 Mb Chr 12: 4.59 – 4.71 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Intersectin-2 is a protein that in humans is encoded by the ITSN2 gene.[3][4][5]

This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. Alternatively spliced transcript variants have been found for this gene that encode three distinct isoforms. Additional variants have been found but their full length nature has not been determined.[5]

Interactions[edit]

ITSN2 has been shown to interact with Wiskott-Aldrich syndrome protein.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Pucharcos C, Estivill X, de la Luna S (Aug 2000). "Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis". FEBS Lett. 478 (1–2): 43–51. doi:10.1016/S0014-5793(00)01793-2. PMID 10922467. 
  4. ^ a b McGavin MK, Badour K, Hardy LA, Kubiseski TJ, Zhang J, Siminovitch KA (Dec 2001). "The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis". J Exp Med. 194 (12): 1777–87. doi:10.1084/jem.194.12.1777. PMC 2193569Freely accessible. PMID 11748279. 
  5. ^ a b "Entrez Gene: ITSN2 intersectin 2". 

Further reading[edit]