Individual participant data
Individual participant data (also known as individual patient data, often abbreviated IPD) is a type of meta-analysis in which data is collected line-by-line from each patient in the studies being analyzed. Due to the high level of precision and consistency this approach allows for (which in turn makes it easier for researchers to minimize heterogeneity), it is considered the gold standard of meta-analyses.[1] The other type of meta-analysis relies not on IPD but on aggregate data (AD). Although the AD approach is more traditional, in the 21st century, meta-analyses conducted with IPD (also known as IPD meta-analyses) have become increasingly popular.[2] IPD meta-analyses tend to be for large-scale and international projects, and they are less limited than AD meta-analyses in terms of the availability and quality of data they can use.[3] The International Committee of Medical Journal Editors (ICMJE) has stated that sharing of deidentified individual participant data is an ethical obligation.[4]
References
- ^ Thomas, Doneal; Radji, Sanyath; Benedetti, Andrea (19 June 2014). "Systematic review of methods for individual patient data meta- analysis with binary outcomes". BMC Medical Research Methodology. 14 (1). doi:10.1186/1471-2288-14-79.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ Riley, R. D.; Lambert, P. C.; Abo-Zaid, G. (5 February 2010). "Meta-analysis of individual participant data: rationale, conduct, and reporting". BMJ. 340 (feb05 1): c221–c221. doi:10.1136/bmj.c221.
- ^ Tierney, Jayne F.; Pignon, Jean-Pierre; Gueffyier, Francois; Clarke, Mike; Askie, Lisa; Vale, Claire L.; Burdett, Sarah (November 2015). "How individual participant data meta-analyses have influenced trial design, conduct, and analysis". Journal of Clinical Epidemiology. 68 (11): 1325–1335. doi:10.1016/j.jclinepi.2015.05.024.
- ^ Taichman, Darren B.; Backus, Joyce; Baethge, Christopher; Bauchner, Howard; de Leeuw, Peter W.; Drazen, Jeffrey M.; Fletcher, John; Frizelle, Frank A.; Groves, Trish; Haileamlak, Abraham; James, Astrid; Laine, Christine; Peiperl, Larry; Pinborg, Anja; Sahni, Peush; Wu, Sinan (2016). "Sharing Clinical Trial Data: A Proposal From the International Committee of Medical Journal Editors". Annals of Internal Medicine. 164 (7): 505. doi:10.7326/M15-2928. ISSN 0003-4819.
External links
- Individual participant data meta-analysis information at the Cochrane website
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