Ionomycin

Ionomycin
Names
	IUPAC name calcium (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-19,21-dihydroxy-22-{(2S,2'R,5S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxodocosa-10,16-dienoate
Identifiers
CAS Number	56092-82-1;
3D model (JSmol)	Interactive image;
ECHA InfoCard	100.121.228
PubChem CID	6446270;
CompTox Dashboard (EPA)	DTXSID101017257 ;
	SMILES CC(CCC(=O)[O-])CC(C)CC(C)C(=O)C=C(C(C)CC(C)CC=CC (C)C(C(C)C(CC1CCC(O1)(C)C2CCC(O2)(C)C(C)O)O)O)[O-].[Ca+2];
Properties
Chemical formula	C41H70CaO9
Molar mass	747.0671
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus ^[1]. It is used in research to raise the intracellular level of calcium (Ca²⁺) and as a research tool to understand Ca²⁺ transport across biological membranes. It is also used to stimulate the intracellular production of the cytokines interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA. These cytokines are important in the inflammatory response.

Commercially, Ionomycin can be obtained as a free acid, or as a Ca²⁺ salt.

References

^ See Ionomycin Calcium salt from Fermentek, manufacturer's product page for ionomycin

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[1] See Ionomycin Calcium salt from Fermentek, manufacturer's product page for ionomycin

[1]