Ionomycin
Appearance
![]() | |
Names | |
---|---|
IUPAC name
calcium (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-19,21-dihydroxy-22-{(2S,2'R,5S,5'S)-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyloctahydro-2,2'-bifuran-5-yl}-4,6,8,12,14,18,20-heptamethyl-11-oxido-9-oxodocosa-10,16-dienoate
| |
Identifiers | |
3D model (JSmol)
|
|
ECHA InfoCard | 100.121.228 |
PubChem CID
|
|
CompTox Dashboard (EPA)
|
|
| |
Properties | |
C41H70CaO9 | |
Molar mass | 747.0671 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
Ionomycin is an ionophore produced by the bacterium Streptomyces conglobatus [1]. It is used in research to raise the intracellular level of calcium (Ca2+) and as a research tool to understand Ca2+ transport across biological membranes. It is also used to stimulate the intracellular production of the cytokines interferon, perforin, IL-2, and IL-4 usually in conjunction with PMA. These cytokines are important in the inflammatory response.
Commercially, Ionomycin can be obtained as a free acid, or as a Ca2+ salt.
References
- ^ See Ionomycin Calcium salt from Fermentek, manufacturer's product page for ionomycin