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Kallikrein-related peptidase 12
Symbols KLK12 ; KLK-L5; KLKL5
External IDs OMIM605539 MGI1916761 HomoloGene44690 ChEMBL: 4943 GeneCards: KLK12 Gene
RNA expression pattern
PBB GE KLK12 220782 x at tn.png
More reference expression data
Species Human Mouse
Entrez 43849 69511
Ensembl ENSG00000186474 ENSMUSG00000044430
UniProt Q9UKR0 B2RVZ0
RefSeq (mRNA) NM_019598 NM_027097
RefSeq (protein) NP_062544 NP_081373
Location (UCSC) Chr 19:
51.03 – 51.04 Mb
Chr 7:
43.77 – 43.77 Mb
PubMed search [1] [2]

Kallikrein-12 is a protein that in humans is encoded by the KLK12 gene.[1][2][3]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms.[3]


  1. ^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. 
  2. ^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. 
  3. ^ a b "Entrez Gene: KLK12 kallikrein-related peptidase 12". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: S01.020