KLK12

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KLK12
Identifiers
AliasesKLK12, KLK-L5, KLKL5, kallikrein related peptidase 12
External IDsMGI: 1916761 HomoloGene: 44690 GeneCards: KLK12
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for KLK12
Genomic location for KLK12
Band19q13.41Start51,029,092 bp[1]
End51,035,230 bp[1]
RNA expression pattern
PBB GE KLK12 220782 x at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_019598
NM_145894
NM_145895

NM_027097

RefSeq (protein)

NP_062544
NP_665901
NP_665902

NP_081373

Location (UCSC)Chr 19: 51.03 – 51.04 MbChr 7: 43.77 – 43.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kallikrein-12 is a protein that in humans is encoded by the KLK12 gene.[5][6][7]

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in three transcript variants encoding different isoforms.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186474 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044430 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, Fritz H, Lilja H, Malm J, Maltais LJ, Olsson AY, Petraki C, Scorilas A, Sotiropoulou G, Stenman UH, Stephan C, Talieri M, Yousef GM (Jun 2006). "A comprehensive nomenclature for serine proteases with homology to tissue kallikreins". Biol Chem. 387 (6): 637–41. doi:10.1515/BC.2006.082. PMID 16800724. 
  6. ^ Diamandis, Eleftherios P.; Deperthes, David; Lundwall, Åke (Jun 2006). "Proceedings of the 1st International Symposium on Kallikreins, Lausanne, Switzerland, September 1-3 , 2005". Biol Chem. 387 (6): 635–824. doi:10.1515/BC.2006.081. PMID 16800723. 
  7. ^ a b "Entrez Gene: KLK12 kallikrein-related peptidase 12". 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: S01.020