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Kari Nadeau

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Kari Nadeau
NationalityAmerican
Alma mater
Known forAllergy Prevention & Treatment
Scientific career
Fields
  • Allergy / Immunology
  • Food Allergy Desensitization
  • Oral Immunotherapy
  • Airborne Pollution and Asthma
InstitutionsHarvard University
Stanford University
ThesisBiochemical studies on protein folding chaperones : Hsp90 and cyclophilin ; and, On trypanosomal enzymes : trypanothione and glutationylspermidine synthetases (1995)
Doctoral advisorChristopher T. Walsh

Kari C. Nadeau is the Chair of the Department of Environmental Health at Harvard School of Public Health and John Rock Professor of Climate and Population Studies.[1] She is adjunct professor at Stanford University in the Department of Pediatrics[2] and the co-chair of the Medical Societies Consortium for Climate Change and Health.[3] She practices Allergy, Asthma, Immunology in children and adults. She has published over 400+ papers, many in the field of climate change and health.[4] Her team focuses on quantifying health outcomes of solutions as they pertain climate change mitigation and adaptation at the local, regional, country, and global levels. Dr. Nadeau, with a team of individuals and patients and families, has been able to help major progress and impact in the clinical fields of immunology, infection, asthma, and allergy. Dr. Nadeau is a member of the National Academy of Medicine[5] and the U.S. EPA Children’s Health Protection Committee.[6]

For more than 30 years, she has devoted herself to understanding how environmental and genetic factors affect the risk of developing human disease. Her laboratory has been studying pollution effects on children and adults. Many of the health issues involving individuals and the public are increasing because of global warming, and extreme weather conditions. She oversees a team working with a multidisciplinary group of community leaders, engineers, scientists, lawyers, and policy makers. Dr. Nadeau was appointed as a member of the U.S. Federal Wildfire Commission in 2022.[7]

Dr. Nadeau works with other organizations and institutes across the world. She works with the WHO on a scoping review and report for health ministers and policy makers on wildland fires and/or air pollution: how to mitigate, adapt, and follow UN SDG’s to create resiliency and co-benefits in communities, especially LMICs.

Dr. Nadeau and her team perform research in the prevention and therapy of disease. She also launched four biotech companies,[8][9][10] and founded the Climate Change and Health Equity Task Force and started the Sustainability Health Seed Grant initiative and Climate Change and Health Fellowship program.[11] She also developed climate change and health courses, including a global masters class to teach Climate and Sustainability around the globe. She has served on the Scientific Advisory Board of the U.S. EPA.

She works as a member of the UNEA through Harvard to work on environmental health and planetary health governance and policy.[12] She is also a member of the Center for the Early Development of the Child scientific committee at Harvard.[13]

Dr. Nadeau is a Faculty Associate at The Salata Institute for Climate and Sustainability and works with the Harvard Global Health Initiative and with the FXB center for Health and Human Rights at Harvard University. She is the director of the Harvard Center for Climate, Health and the Global Environment. Through these programs Dr. Nadeau works directly with Environmental Justice, global,  regional, and local communities.

Her groundbreaking research has pioneered the field of allergies, asthma, and immunology, specifically in food allergies, pollution-induced asthma, and COVID-19. Dr. Nadeau’s studies have demonstrated that exposures to water and air pollution can modify the DNA of all ages of individuals and can lead to respiratory, allergic, and immune disorders.[14]

With her laboratory and team, Dr. Nadeau conducted research showing prescribed burns vs wildfire smoke was less harmful to communities.[15] She also was responsible for running the first clinical trial to treat multiple food allergies. Dr. Nadeau and her laboratory discovered novel mechanisms of STAT5a and STAT5b transcriptional factors to help understand the human immune system.[16]

Education

[edit]

After graduating from Haverford College with a degree in biology,[17] Nadeau attended Harvard Medical School via the Medical Scientist Training Program (NIH), and received a PhD in biological chemistry and molecular pharmacology and an MD in 1995. She then started an internship and residency in pediatrics. From 1998 to 2002, she worked in the field of biopharmaceuticals and led clinical research to obtain FDA approval for two biologics in the field of Autoimmunity and Oncology, respectively. From 2003 to 2006, Nadeau was a pediatric resident and a fellow in Asthma, Allergy, and Immunology. She also did a postdoctoral fellowship in human immune tolerance mechanisms in asthma and allergy.[18] She received a certificate in Public Policy from the Harvard Kennedy School in 2022.

Career

[edit]

In 2006, Nadeau was appointed to the Stanford University School of Medicine with appointments in Pediatrics and Otolaryngology. In 2016 she was named the Naddisy Foundation Professor of Pediatric Food Allergy, Immunology and Asthma endowed professorship under the Naddisy Family Foundation.[19] Nadeau has served as a reviewer for NIH Study Sections, and a member of the American Lung Association Medical Board, CA. She serves on the Environmental Health Policy committee for the American Thoracic Society and is a Fellow in the American Academy of Allergy, Asthma and Immunology and is a member of ASCI (American Society of Clinical Investigation).[20] Her laboratory focuses on the study of immunological mechanisms involved in the cause, diagnosis, and therapy for allergy and asthma.[21] In December, 2014 Sean Parker donated $24 million to Stanford to establish the Sean N. Parker Center for Allergy Research at Stanford University,[22] with Nadeau as the director.[23][24]

In September 2020, Dr. Kari Nadeau published The End of Food Allergy: The First Program To Prevent and Reverse a 21st Century Epidemic with co-author Sloan Barnett.[25]

As of January 2023, Nadeau is Chair of the Department of Environmental Health at Harvard TH Chan School of Public Health. [26]

She is currently on the Scientific Advisory Board of Seed.

Research

[edit]

Monitoring cells and responses in human immunotherapy and their effect on immune tolerance

[edit]

Translational work (through conducting novel and innovative clinical studies to induce tolerance through immunotherapy) on Treg function and epigenetic changes.[27][28][29] This research led to novel findings on markers of immune tolerance in clinical trial using food  oral immunotherapy for near fatal food allergies. Dr. Nadeau and her team study how immune cells respond to therapy using human blood and organoids.

Multiple Pollution Exposomics

[edit]

Dr. Nadeau oversees collaborative teams examining plasma, cellular, and epigenetic markers that are affected by pollution in children, adolescents, and adults. Using well characterized cohorts across the world (for acute pollution exposure—i.e. wildfire) and in the Central Valley of California (for chronic exposure—i.e. Fresno is one of the highest ranked cities in the country for PM2.5 air pollution), Dr. Nadeau and her team have been able to perform innovative and impactful research that has helped shape public policy towards mitigating pollution and its effects on the public, (especially those at risk populations (like children) and the underserved (like Hispanic populations in the Central Valley of California).[30][31][32][33]

Solutions in Climate Change Mitigation and Adaptation

[edit]

Working with a team of dedicated multidisciplinary experts, Dr. Nadeau focuses on quantifying the health outcomes of solutions that have been implemented to address climate change. For example, her team studies whether certain diseases are lessened by switching from diesel to electric vehicles, from gas to electric stoves, from no to cooling devices, or from no biodiversity to greening a local area. She focuses her research on those communities that are inequitably exposed to climate change and extreme weather. [34][35][36][37][38]

Honors and awards

[edit]
  • 2006 Parker B. Francis Fellowship to Faculty Award[39]
  • 2008 American Academy of Allergy, Asthma, and Immunology (AAAAI) Award for Junior Faculty[40]
  • 2008 McCormick Award, Stanford University School of Medicine[41]
  • 2010 Environmental Protection Agency (EPA) STAR Grant Award[42]
  • 2010 Elected to Collegium Internationale Allergologicum (CIA)[43]
  • 2014 Distinguished Lecture Award, NIEHS Annual Distinguished Lecture[44]
  • 2015 Elected into American Society of Clinical Investigation (ASCI)[45]
  • 2018 Chairman, Gordon Research Conference, Food Allergy[46]
  • 2019 Senior Fellow, Stanford Woods Institute for the Environment[47]
  • 2019: Elected into the American Association of Physicians
  • 2022 Elected into the National Academy of Medicine[48]
  • 2023 Asian Pacific Association for Asthma, Allergy and Clinical Immunology Women in Science Award
  • 2023 AAAAI Foundation and Richard F. Lockey Lectureship award
  • 2023 Beth Israel Deaconess Lahey Hospitals and Clinics - Environmental Sustainability Award and Plenary Speaker
  • 2023 Paul Ehrlich International Award for Research [49]

Media

[edit]

Nadeau and her work have made a number of media appearances supporting food allergy awareness and research:

  • New York Times, The Allergy Buster[50]
  • CNN, Funding a cure for food allergies[51]
  • Huffington Post,[52][53]
  • 60 Minutes, Allergy Free[54]
  • NBC News, Food Allergy Treatments for Children Show Promise[55]
  • Forbes, How Giving Children Foods They Are Allergic To Can Cure Them, And Other Provocative Approaches In Evolutionary Medicine[56]
  • PBS Newshour, Retraining the body to lift the life sentence of food allergies[57]
  • US News, New Hope for Kids With Multiple Food Allergies[58]
  • CBS Boston, HealthWatch: New Treatment To Help Kids With Multiple Food Allergies[59]
  • TEDxPaloAlto, Let's Focus on Food Allergy Prevention[60]
  • After On podcast, Episode 46 - Dr. Kari Nadeau - Defeating food allergy[61]
  • Today show, A peanut allergy cure? Big news on new treatments for 6 million kids[62]
  • Today show, Allergy prevention: The fascinating method parents are turning to.[63]
  • TEDx – Planetary Stewardship[64]

References

[edit]
  1. ^ "Kari C Nadeau". Harvard T.H. Chan School of Public Health. 2023-01-21. Retrieved 2024-01-02.
  2. ^ "Kari Nadeau, MD, PhD's Profile | Stanford Profiles". profiles.stanford.edu. Retrieved 2024-01-08.
  3. ^ "Meet Our Team". The Medical Society Consortium on Climate and Health (MSCCH). Retrieved 2024-01-08.
  4. ^ "Kari Nadeau". connects.catalyst.harvard.edu. Retrieved 2024-01-02.
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  14. ^ Aguilera, Juan; Han, Xiaorui; Cao, Shu; Balmes, John; Lurmann, Fred; Tyner, Tim; Lutzker, Liza; Noth, Elizabeth; Hammond, S. Katharine; Sampath, Vanitha; Burt, Trevor; Utz, P. J.; Khatri, Purvesh; Aghaeepour, Nima; Maecker, Holden (2022-03-14). "Increases in ambient air pollutants during pregnancy are linked to increases in methylation of IL4, IL10, and IFNγ". Clinical Epigenetics. 14 (1): 40. doi:10.1186/s13148-022-01254-2. ISSN 1868-7083. PMC 8919561. PMID 35287715.
  15. ^ Prunicki, Mary; Kelsey, Rodd; Lee, Justin; Zhou, Xiaoying; Smith, Edward; Haddad, Francois; Wu, Joseph; Nadeau, Kari (October 2019). "The Impact of Prescribed Fire versus Wildfire on the Immune and Cardiovascular Systems of Children". Allergy. 74 (10): 1989–1991. doi:10.1111/all.13825. ISSN 0105-4538. PMC 6801011. PMID 31002401.
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  18. ^ Nadeau, Kari C.; Callejas, Angel; Wong, Wendy B.; Joh, Jae Won; Cohen, Harvey J.; Jeng, Michael R. (December 2008). "Idiopathic neutropenia of childhood is associated with Fas/FasL expression". Clinical Immunology. 129 (3): 438–447. doi:10.1016/j.clim.2008.08.006. ISSN 1521-6616. PMC 4161459. PMID 18819843.
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  22. ^ "Sean Parker Center". Med.stanford.edu. Retrieved 2015-05-13.
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  24. ^ "Why Sean Parker Gave $24 Million To Build A Stanford Allergy Research Center". Forbes.com. Retrieved 3 May 2015.
  25. ^ Nadeau, Kari; Barnett, Sloan (2020). The End of Food Allergy. Penguin. ISBN 978-0593189511.
  26. ^ "Department of Environmental Health". Department of Environmental Health. 2024-01-16. Retrieved 2024-01-02.
  27. ^ Kaushik, Abhinav; Dunham, Diane; Han, Xiaorui; Do, Evan; Andorf, Sandra; Gupta, Sheena; Fernandes, Andrea; Kost, Laurie Elizabeth; Sindher, Sayantani B.; Yu, Wong; Tsai, Mindy; Tibshirani, Robert; Boyd, Scott D.; Desai, Manisha; Maecker, Holden T. (2022-11-04). "CD8+ T cell differentiation status correlates with the feasibility of sustained unresponsiveness following oral immunotherapy". Nature Communications. 13 (1): 6646. doi:10.1038/s41467-022-34222-8. ISSN 2041-1723. PMC 9636180. PMID 36333296.
  28. ^ Prunicki, Mary; Cauwenberghs, Nicholas; Ataam, Jennifer Arthur; Movassagh, Hesam; Kim, Juyong Brian; Kuznetsova, Tatiana; Wu, Joseph C.; Maecker, Holden; Haddad, Francois; Nadeau, Kari (2022-11-28). "Correction: Immune biomarkers link air pollution exposure to blood pressure in adolescents". Environmental Health. 21 (1): 117. Bibcode:2022EnvHe..21..117P. doi:10.1186/s12940-022-00916-1. ISSN 1476-069X. PMC 9703689. PMID 36443731.
  29. ^ Akdis, Cezmi A.; Akdis, Mübeccel; Boyd, Scott D.; Sampath, Vanitha; Galli, Stephen J.; Nadeau, Kari C. (2023). "Allergy: Mechanistic insights into new methods of prevention and therapy". Science Translational Medicine. 15 (679): eadd2563. doi:10.1126/scitranslmed.add2563. PMID 36652536. S2CID 255966491. Retrieved 2024-01-02.
  30. ^ Aguilera, Juan; Han, Xiaorui; Cao, Shu; Balmes, John; Lurmann, Fred; Tyner, Tim; Lutzker, Liza; Noth, Elizabeth; Hammond, S. Katharine; Sampath, Vanitha; Burt, Trevor; Utz, P. J.; Khatri, Purvesh; Aghaeepour, Nima; Maecker, Holden (2022-03-14). "Increases in ambient air pollutants during pregnancy are linked to increases in methylation of IL4, IL10, and IFNγ". Clinical Epigenetics. 14 (1): 40. doi:10.1186/s13148-022-01254-2. ISSN 1868-7083. PMC 8919561. PMID 35287715.
  31. ^ Jung, Youn Soo; Sampath, Vanitha; Prunicki, Mary; Aguilera, Juan; Allen, Harry; LaBeaud, Desiree; Veidis, Erika; Barry, Michele; Erny, Barbara; Patel, Lisa; Akdis, Cezmi; Akdis, Mubeccel; Nadeau, Kari (2022-12-15). "Characterization and regulation of microplastic pollution for protecting planetary and human health". Environmental Pollution. 315: 120442. doi:10.1016/j.envpol.2022.120442. ISSN 0269-7491. PMID 36272609. S2CID 253037874.
  32. ^ Goshua, Anna; Akdis, Cezmi A.; Nadeau, Kari C. (July 2022). "World Health Organization global air quality guideline recommendations: Executive summary". Allergy. 77 (7): 1955–1960. doi:10.1111/all.15224. ISSN 1398-9995. PMID 35060140. S2CID 240245347.
  33. ^ Movassagh, Hesam; Prunicki, Mary; Kaushik, Abhinav; Zhou, Xiaoying; Dunham, Diane; Smith, Eric M.; He, Ziyuan; Aleman Muench, German R.; Shi, Minyi; Weimer, Annika K.; Cao, Shu; Andorf, Sandra; Feizi, Amir; Snyder, Michael P.; Soroosh, Pejman (July 2023). "Proinflammatory polarization of monocytes by particulate air pollutants is mediated by induction of trained immunity in pediatric asthma". Allergy. 78 (7): 1922–1933. doi:10.1111/all.15692. ISSN 1398-9995. PMID 36929161. S2CID 257580769.
  34. ^ Agache, Ioana; Sampath, Vanitha; Aguilera, Juan; Akdis, Cezmi A.; Akdis, Mubeccel; Barry, Michele; Bouagnon, Aude; Chinthrajah, Sharon; Collins, William; Dulitzki, Coby; Erny, Barbara; Gomez, Jason; Goshua, Anna; Jutel, Marek; Kizer, Kenneth W. (May 2022). "Climate change and global health: A call to more research and more action". Allergy. 77 (5): 1389–1407. doi:10.1111/all.15229. ISSN 1398-9995. PMID 35073410. S2CID 246277357.
  35. ^ Perera, Frederica; Nadeau, Kari (2022-06-16). Solomon, Caren G.; Salas, Renee N. (eds.). "Climate Change, Fossil-Fuel Pollution, and Children's Health". New England Journal of Medicine. 386 (24): 2303–2314. doi:10.1056/NEJMra2117706. ISSN 0028-4793. PMID 35704482.
  36. ^ Lee, Alexandra S.; Aguilera, Juan; Efobi, Jo Ann; Jung, Youn Soo; Seastedt, Hana; Shah, Mihir M.; Yang, Emily; Konvinse, Katherine; Utz, Paul J.; Sampath, Vanitha; Nadeau, Kari C. (2023-04-05). "Climate change and public health: The effects of global warming on the risk of allergies and autoimmune diseases: The effects of global warming on the risk of allergies and autoimmune diseases". EMBO Reports. 24 (4): e56821. doi:10.15252/embr.202356821. ISSN 1469-3178. PMC 10074113. PMID 36847605.
  37. ^ Sarabu, Chethan; Deonarine, Andrew; Leitner, Stefano; Fayanju, Oluseyi; Fisun, Myroslava; Nadeau, Kari (2022-11-14). "Climate change and health informatics: pilot survey of perspectives across the field". Journal of the American Medical Informatics Association. 29 (12): 2117–2123. doi:10.1093/jamia/ocac199. ISSN 1527-974X. PMC 9667170. PMID 36264269.
  38. ^ Akdis, Cezmi A.; Nadeau, Kari C. (November 2022). "Human and planetary health on fire". Nature Reviews Immunology. 22 (11): 651–652. doi:10.1038/s41577-022-00776-3. ISSN 1474-1741. PMC 9425797. PMID 36042380.
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  45. ^ "The ASCI's 2015 ballot results". ASCI. 22 March 2015. Retrieved 22 January 2018.
  46. ^ "2018 Food Allergy Conference GRC". www.grc.org. Retrieved 2018-01-15.
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  57. ^ "Retraining the body to lift the life sentence of food allergies". Video.pbs.org. Retrieved 12 May 2015.
  58. ^ "New Hope for Kids With Multiple Food Allergies". Archived from the original on 2018-01-16.
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  60. ^ "Let's Focus on Food Allergy Prevention | TEDx". YouTube.
  61. ^ "After On Episode 46". 9 April 2019.
  62. ^ "A peanut allergy cure? Big news on new treatments for 6 million kids".
  63. ^ "Allergy prevention: The fascinating method parents are turning to".
  64. ^ "Planetary Stewardship November 2023". TEDxBoston. Retrieved 2024-01-02.
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