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Leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5
Symbols LILRB5 ; CD85C; LIR-8; LIR8
External IDs OMIM604814 HomoloGene134027 GeneCards: LILRB5 Gene
RNA expression pattern
PBB GE LILRB5 206856 at tn.png
More reference expression data
Species Human Mouse
Entrez 10990 n/a
Ensembl ENSG00000105609 n/a
UniProt O75023 n/a
RefSeq (mRNA) NM_001081442 n/a
RefSeq (protein) NP_001074911 n/a
Location (UCSC) Chr 19:
54.25 – 54.26 Mb
PubMed search [1] n/a

Leukocyte immunoglobulin-like receptor subfamily B member 5 is a protein that in humans is encoded by the LILRB5 gene.[1][2]

This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Several other LIR subfamily B receptors are expressed on immune cells where they bind to MHC class I molecules on antigen-presenting cells and inhibit stimulation of an immune response. Multiple transcript variants encoding different isoforms have been found for this gene.[2]


  1. ^ Borges L, Hsu ML, Fanger N, Kubin M, Cosman D (Apr 1998). "A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules". J Immunol 159 (11): 5192–6. PMID 9548455. 
  2. ^ a b "Entrez Gene: LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5". 

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