LMO4

LMO4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L4Z
Identifiers
Aliases	LMO4, LIM domain only 4
External IDs	OMIM: 603129; MGI: 109360; HomoloGene: 4927; GeneCards: LMO4; OMA:LMO4 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	87,348,923 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	143,910,981 bp
RNA expression pattern
	Top expressed in
	dorsolateral prefrontal cortex; ; prefrontal cortex; ; Brodmann area 46; ; superior frontal gyrus; ; parietal lobe; ; postcentral gyrus; ; Brodmann area 9; ; frontal pole; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	granulocyte; ; genital tubercle; ; cingulate gyrus; ; superior frontal gyrus; ; visual cortex; ; primary motor cortex; ; primary visual cortex; ; dentate gyrus of hippocampal formation granule cell; ; CA3 field; ; corneal stroma;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; metal ion binding; protein binding; cis-regulatory region sequence-specific DNA binding; transcription factor binding;
Cellular component	transcription regulator complex; cell leading edge;
Biological process	regulation of transcription, DNA-templated; ventricular septum development; spinal cord association neuron differentiation; thymus development; negative regulation of protein-containing complex assembly; transcription, DNA-templated; ventral spinal cord interneuron differentiation; regulation of cell activation; spinal cord motor neuron differentiation; regulation of cell fate specification; positive regulation of transcription by RNA polymerase II; neural tube closure; transcription by RNA polymerase II; positive regulation of kinase activity; regulation of cell migration;
	Sources:Amigo / QuickGO
Orthologs
	8543
	16911
	ENSG00000143013
	ENSMUSG00000028266
	P61968
	P61969
	NM_006769; NM_001369491
	NM_001161769; NM_001161770; NM_010723
	NP_006760; NP_001356420
	NP_001155241; NP_001155242; NP_034853
	Wikidata
View/Edit Human	View/Edit Mouse

LIM domain transcription factor LMO4 is a protein that in humans is encoded by the LMO4 gene.^[5]

Template:PBB Summary

Interactions

LMO4 has been shown to interact with LDB1,^[6]^[7] RBBP8^[6]^[8] and BRCA1.^[6]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143013 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028266 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: LMO4 LIM domain only 4".
^ ^a ^b ^c Sutherland, Kate D; Visvader Jane E; Choong David Y H; Sum Eleanor Y M; Lindeman Geoffrey J; Campbell Ian G (Oct 2003). "Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas". Int. J. Cancer. 107 (1). United States: 155–8. doi:10.1002/ijc.11343. ISSN 0020-7136. PMID 12925972. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ Deane, Janet E; Mackay Joel P; Kwan Ann H Y; Sum Eleanor Y M; Visvader Jane E; Matthews Jacqueline M (May 2003). "Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4". EMBO J. 22 (9). England: 2224–33. doi:10.1093/emboj/cdg196. ISSN 0261-4189. PMC 156068. PMID 12727888. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)
^ ^a ^b Sum, Eleanor Y M; Peng Benjamin; Yu Xin; Chen Junjie; Byrne Jennifer; Lindeman Geoffrey J; Visvader Jane E (Mar 2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity". J. Biol. Chem. 277 (10). United States: 7849–56. doi:10.1074/jbc.M110603200. ISSN 0021-9258. PMID 11751867. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

Interactions

References

Further reading