LRRC4

LRRC4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DL9, 3ZYI
Identifiers
Aliases	LRRC4, NGL-2, NAG14, leucine rich repeat containing 4
External IDs	OMIM: 610486; MGI: 2182081; HomoloGene: 36403; GeneCards: LRRC4; OMA:LRRC4 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	128,032,107 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	28,831,746 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; prefrontal cortex; ; right frontal lobe; ; bronchial epithelial cell; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; right hemisphere of cerebellum; ; cingulate gyrus; ; anterior cingulate cortex; ; cerebellar vermis;
	Top expressed in
	interventricular septum; ; dentate gyrus of hippocampal formation granule cell; ; visual cortex; ; primary visual cortex; ; piriform cortex; ; cingulate gyrus; ; superior frontal gyrus; ; lobe of cerebellum; ; hippocampus proper; ; primary motor cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein kinase inhibitor activity; protein binding;
Cellular component	cytoplasm; integral component of membrane; neuron spine; cell junction; postsynaptic membrane; dendritic spine; plasma membrane; synapse; excitatory synapse; membrane; Schaffer collateral - CA1 synapse; glutamatergic synapse; integral component of postsynaptic density membrane;
Biological process	synapse organization; postsynaptic density protein 95 clustering; regulation of synapse organization; negative regulation of protein kinase activity; cytokine-mediated signaling pathway; negative regulation of receptor signaling pathway via JAK-STAT; modulation of chemical synaptic transmission; synaptic membrane adhesion; excitatory synapse assembly;
	Sources:Amigo / QuickGO
Orthologs
	64101
	192198
	ENSG00000128594
	ENSMUSG00000049939
	Q9HBW1
	Q99PH1
	NM_022143
	NM_138682
	NP_071426
	NP_619623
	Wikidata
View/Edit Human	View/Edit Mouse

Leucine-rich repeat-containing protein 4 is a protein that in humans is encoded by the LRRC4 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128594 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000049939 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang JR, Li XL, Fan SQ, Tan C, Xiang JJ, Tang K, Wang R, Li GY (Sep 2003). "Expression of LRRC4 has the potential to decrease the growth rate and tumorigenesis of glioblastoma cell line U251". Ai Zheng. 22 (9): 897–902. PMID 12969517.
^ "Entrez Gene: LRRC4 leucine rich repeat containing 4".

References

Further reading