List of side effects of trimethoprim/sulfamethoxazole
Adverse effects by incidence of trimethoprim/sulfamethoxazole [1][2][3][4][5][6][7]
Common (>1% frequency)
- Fever
- Nausea
- Vomiting
- Diarrhea
- Weight loss
- Rash
- Muscle aches
- Joint pain
- Itch
- Sore mouth
- Hyperkalaemia (high blood potassium)
- Thrombocytopenia (low number of platelets in the blood)
Infrequently (0.1–1.0% frequency)
- Headache
- Jaundice
- Elevated liver transaminases
- Peripheral neuritis
- Drowsiness
- Constipation
- Photosensitivity (light sensitivity)
- Blood dyscrasias (e.g. neutropaenia)
Rare (<0.1% frequency)
- Megaloblastic anaemia
- Methaemoglobinaemia
- Erythema multiforme
- Low blood sugar
- Hepatitis (liver swelling)
- Crystalluria (crystals in the urine)
- Urinary obstruction causing difficulty passing urine
- Lowered mental acuity
- Depression
- Tremor
- Aplastic anaemia
- Haemolytic anaemia
- Hyponatraemia
- Purpura
- Eosinophilia
- Agranulocytosis
- Serum sickness
- Anaphylaxis
- Allergic myocarditis
- Angioedema
- Drug fever
- Peri-arteritis nodosa
- Hepatic necrosis
- Pancreatitis
- Myelosuppression
- Haemolysis[a]
- Stevens-Johnson syndrome[b]
- Toxic epidermal necrolysis[c]
- Ataxia[d]
- Clostridium difficile colitis
- Aseptic meningitis[e]
- Pseudomembranous colitis
- Interstitial nephritis
- Fulminant hepatic necrosis
- Hypersensitivity of the respiratory tract
- Sore throat
- Pallor
- Arthralgia
Unknown frequency
- Hallucinations
- Cough
- Glossitis
- Stomatitis
- Fatigue
- Insomnia
- Impaired kidney function
- Pulmonary infiltration[f]
- Shortness of breath
Notes
- ^ Breakdown of red blood cells. This side effect most often occurs in people with glucose-6-phosphate dehydrogenase deficiency
- ^ A potentially fatal skin reaction that causes the skin to slough off
- ^ Basically a worse form of Stevens-Johnson syndrome
- ^ Incoordination; most often after IV use in HIV patients
- ^ Swelling of the membranes surrounding the brain and spinal cord without any obvious infectious cause
- ^ Sign of hypersensitivity
References
- ^ "Bactrim, Bactrim DS (trimethoprim/sulfamethoxazole) dosing, indications, interactions, adverse effects, and more". Medscape Reference. WebMD. Retrieved 13 January 2014.
- ^ "BACTRIM®" (PDF). TGA eBusiness Services. Roche Products Pty Limited. 18 September 2012. Retrieved 13 January 2014.
- ^ "BACTRIM DS (sulfamethoxazole and trimethoprim) tablet BACTRIM (sulfamethoxazole and trimethoprim) tablet [AR Scientific, Inc.]". DailyMed. AR Scientific, Inc. June 2013. Retrieved 13 January 2014.
- ^ "Co-Trimoxazole Tablets 80/400mg - Summary of Product Characteristics (SPC)". electronic Medicines Compendium. Actavis UK Ltd. 17 October 2012. Retrieved 13 January 2014.
- ^ Joint Formulary Committee (2013). British National Formulary (BNF) (65 ed.). London, UK: Pharmaceutical Press. ISBN 978-0-85711-084-8.
- ^ Rossi, S, ed. (2013). Australian Medicines Handbook (2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust. ISBN 978-0-9805790-9-3.
- ^ "e-Therapeutics+e-CPS". Sulfamethoxazole-Trimethoprim CPhA Monograph. Retrieved 28 March 2015.