Lloyd Mayer

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Lloyd Mayer
Lloyd Mayer, Co-Director of the Immunology Institute at Mount Sinai
BornJune 21, 1952
DiedSeptember 5, 2013
EducationUnion College
Mount Sinai School of Medicine
Years active1976-2013
Known forCrohn's disease, colitis, inflammatory bowel disease, CCFA, gp180, immunology, immunobiology, gastroenterology
Medical career
Professiongastroenterologist and immunologist
InstitutionsMount Sinai Medical Center
ResearchCrohns Disease, Colitis, Inflammatory Bowel Disease, CCFA, gp180, Immunology, Immunobiology, Gastroenterology
AwardsGraduated from the Icahn School of Medicine at Mount Sinai in 1976 and received the Mosby Award for Clinical Excellence at that time. Saul Horowitz Award, Irma T. Hirschl Trust Career Development Award, Jeffrey Modell Foundation Lifetime Achievement Award, Jaffe Food Allergy Institute Award for Scientific Excellence, Crohn's and Colitis Foundation of America (CCFA) Scientific Achievement Award, Chief of the Division of Clinical Immunology at Mount Sinai, Vice Chair of Medicine at Mount Sinai, David and Dorothy Merksamer Professor of Medicine in 1994, Professor of Immunobiology and Chair of the Immunobiology Center, Chief of the Division of Gastroenterology from 2003 to 2010, Professor and Co-Director of the Immunology Institute. Chairman of the National Scientific Advisory Committee of the CCFA from 2008-2012.

Lloyd Mayer (June 21, 1952 – September 5, 2013) was an American gastroenterologist and immunologist. He was Professor and Co-Director of the Immunology institute at the Mount Sinai Medical Center, now known as the Lloyd Mayer Immunology Institute.[1]

Mayer's research on inflammatory bowel disease pathogenesis was among the first to demonstrate the role played by T-regulatory cells in setting the stage for chronic mucosal inflammation (IBD).[2] He was the first to describe the role of T cells in immunoglobulin class switching and to identify a novel T-cell-derived cytokine (446-BCDF) that stimulates antibody secretion by human B cells.[3]

Mayer was Professor and Co-Director of the Immunology institute at the Mount Sinai Medical Center and the Dorothy and David Merksamer Professor of Medicine, as well as Professor of Microbiology at the Mount Sinai School of Medicine.[4]

Mayer was the author of multiple book chapters and close to 200 peer-reviewed papers. He has been included in New York Magazine’s list of Best Doctors since its inception in the 1990s.[5]

Dr. Mayer died following a three-year battle with brain cancer (Glioblastoma) in September 2013.


Mayer was born in 1952. He earned his medical degree from the Mount Sinai School of Medicine in 1976. He completed an internship and a residency in Internal Medicine at Bellevue Hospital Center/New York University in 1979 and a fellowship in Gastroenterology at the Mount Sinai Medical Center in 1981.[6]

Mayer held an appointment at the Rockefeller University from 1980–1984, first as a post-doctoral fellow then Assistant Professor.[6] He was Associate Professor of Medicine and Microbiology at Mount Sinai Medical Center from 1985–1986 and was named Director of the Division of Clinical Immunology in 1986. He was named Professor of both Medicine and Microbiology in 1990, then Vice Chair of Medicine. In 1994, he became the David and Dorothy Merksamer Chair of Medicine, and in 1997, Professor of Immunobiology and Chair of Mount Sinai's Immunobiology Center.

From 1992–1997, Mayer served on the Immunological Sciences Study Section of the National Institutes of Health.[4]

Mayer served as Director of the Mount Sinai's Division of Gastroenterology from 2003–2010. In 2007, he was named Co-Director of Mount Sinai's Immunology Institute. He has served as Chairman of the National Scientific Advisory Committee of the Crohn's & Colitis Foundation of America since 2008.[7]

Mayer was elected to the American Society for Clinical Investigation in 1991 and the Association of American Physicians in 1997.[6][8][9] He was an active member of the American Board of Internal Medicine and Gastroenterology at the time of his death.[4]

Honors and awards[edit]

Current research[edit]


A partial list of active grants on which Mayer is a principal or co-investigator:

  • Immunologic Basis of Cow Milk-Induced Hypersensitivities, NIH/NIAD, 5 U19 AI044236-11
  • Innate/Adaptive Immune Interaction in Gut Inflammation, NIH/NIDDK, 5 P01 DK072201-04
  • Cellular & Molecular Defects in Human B Cell Development, NIH/NIAID, 5 P01 AI061093-05
  • Immunobiology of Peanut Allergy and its Treatment: A Prototype, NIH/NIAID, 1 U19 AI066738-03
  • Epithelial TLR Signaling and IgA Production, NIH/NIAID, 1 R21 AI083381-01
  • Oral Vaccine Platform for Class A Bacterial Agents, NIH, 1 R01 AI084952
  • Generation and Characterization of Intestinal CD8+ Regulatory T cell lines, NIH 1 RC1 DK086605

Clinical trials[edit]

Active clinical trials include:

  • Infliximab for post-op recurrence of Crohn's disease


Partial list:


  1. ^ Obituary in Inflammatory Bowel Diseases journal
  2. ^ Mayer L, Eisenhardt D (October 1990). "Lack of induction of suppressor T cells by intestinal epithelial cells from patients with inflammatory bowel disease". J. Clin. Invest. 86 (4): 1255–60. doi:10.1172/JCI114832. PMC 296856. PMID 2145321.
  3. ^ a b "Faculty biographies" (PDF). 12th International Symposium on Functional Medicine. functionalmedicine.org. November 29, 2004. Retrieved September 21, 2011.
  4. ^ a b c d e f "The Mount Sinai Medical Center". Archived from the original on May 28, 2011. Retrieved September 21, 2011.
  5. ^ "Castle Connolly Medical Ltd". Retrieved September 21, 2011.
  6. ^ a b c "Foundation for Clinical Research in Inflammatory Bowel Disease". Retrieved September 21, 2011.
  7. ^ "The Crohn's & Colitis Foundation Granted $5.6 million by The Leona M. & Harry B. Helmsley Charitable Trust". Crohn's and Colitis Foundation of America. April 21, 2009. Archived from the original on September 27, 2011. Retrieved September 21, 2011.
  8. ^ "The American Society for Clinical Investigation". Retrieved September 21, 2011.
  9. ^ Ken Krizner (July 10, 2009). "Modern Medicine". Modern Medicine. Retrieved September 21, 2011.

External links[edit]