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Lock-on, Lock-On or Lock On may refer to:
- Radar lock-on, where a radar automatically tracks a selected target
- Lock-on (protest tactic), when one or more protesters locks themselves to an inanimate object
- Lock-on, a tactic in action video games where the player character targets an enemy, causing all movement to revolve around that enemy.
- Lock-On (video game), an arcade, PC, and Atari ST game
- Lock On: Modern Air Combat, a PC flight simulator
- Super Air Diver, an SNES video game called Lock On in North America
- Lock-On Technology, a video game cartridge connection technology, used in Sonic & Knuckles for Sega Mega Drive
- Sega Lock-On, a laser-tag game
- Lockon Stratos, a Mobile Suit Gundam 00 character
| disambiguation page lists articles associated with the title Lock-on.
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