Lorena is a municipality/county in the state of São Paulo in Brazil. The population in 2012 is 82,553, the density is 199.5/km² and the area is 413.7 km². The elevation is 524 m.
The city was originated when a farm was constructed at the end of the 17th century. It became a parish in 1718, a municipality in 1788 and is a city since 1856. The city is now the seat of the Roman Catholic Diocese of Lorena. Its main business areas are industry, services and agro-business. It is also a highlight in region due to its three colleges, including areas from human to exact sciences.