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Louis Dubois may refer to:
- Louis DuBois (Huguenot) (died 1696), Huguenot colonist in New Netherland
- Louis Dubois (painter) (1830–1880), Belgian painter
- Louis Dubois (politician) (1859–1946), French Minister of Commerce, Industry, Posts, and Telegraphs
- Louis-Ernest Dubois (1856–1929), Roman Catholic Cardinal and Archbishop of Paris
- Louis Victor Dubois (1837–1914), French politician
- Lewis DuBois, American Revolutionary War commander
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