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Lysias can refer to several people.
- Lysias (born c. 440 BC; died c. 380 BC), an Attic orator
- Lysias (Syrian chancellor), chancellor of the Seleucid Empire, enemy of the Maccabees
- Claudius Lysias, a figure mentioned in the New Testament book of the Acts of the Apostles
- Lysias Anicetus, an Indo-Greek king
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