MAPRE3

MAPRE3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WYO, 3CO1, 3JAK, 3JAL, 3JAR, 3TQ7
Identifiers
Aliases	MAPRE3, EB3, EBF3, EBF3-S, RP3, microtubule associated protein RP/EB family member 3
External IDs	OMIM: 605788 MGI: 2140967 HomoloGene: 56565 GeneCards: MAPRE3
Gene location (Human)
Chr.	Chromosome 2 (human)
End	27,027,219 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	31,023,450 bp
RNA expression pattern
	Top expressed in
	Brodmann area 10; ; right uterine tube; ; middle frontal gyrus; ; frontal pole; ; cingulate gyrus; ; anterior pituitary; ; cerebellar vermis; ; nucleus accumbens; ; Brodmann area 9; ; amygdala;
	Top expressed in
	superior frontal gyrus; ; cerebellar cortex; ; spermatid; ; entorhinal cortex; ; lip; ; dorsomedial hypothalamic nucleus; ; habenula; ; superior colliculus; ; primary motor cortex; ; subiculum;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	microtubule binding; protein binding; identical protein binding; protein C-terminus binding; protein kinase binding; microtubule plus-end binding;
Cellular component	microtubule cytoskeleton; microtubule plus-end; perinuclear region of cytoplasm; cytoplasmic microtubule; midbody; microtubule; cytoskeleton; cytoplasm; microtubule organizing center; spindle midzone; mitotic spindle astral microtubule end;
Biological process	positive regulation of transcription, DNA-templated; cell cycle; positive regulation of microtubule plus-end binding; positive regulation of cyclin-dependent protein serine/threonine kinase activity; cell division; protein localization; regulation of microtubule polymerization or depolymerization; protein localization to microtubule; positive regulation of protein kinase activity; spindle assembly; protein localization to microtubule plus-end;
	Sources:Amigo / QuickGO
Orthologs
	22924
	100732
	ENSG00000084764
	ENSMUSG00000029166
	Q9UPY8
	Q6PER3
	NM_001303050; NM_012326
	NM_133350; NM_001310516
	NP_001289979; NP_036458
	NP_001297445; NP_579928
	Wikidata
View/Edit Human	View/Edit Mouse

Microtubule-associated protein RP/EB family member 3 is a protein that in humans is encoded by the MAPRE3 gene.^[5]^[6]

The protein encoded by this gene is a member of the RP/EB family of genes. The protein localizes to the cytoplasmic microtubule network and binds APCL, a homolog of the adenomatous polyposis coli tumor suppressor gene.^[6]

References[edit]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000084764 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029166 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Renner C, Pfitzenmeier JP, Gerlach K, Held G, Ohnesorge S, Sahin U, Bauer S, Pfreundschuh M (Aug 1997). "RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells". J Immunol. 159 (3): 1276–83. doi:10.4049/jimmunol.159.3.1276. PMID 9233623. S2CID 23797920.
^ ^a ^b "Entrez Gene: MAPRE3 microtubule-associated protein, RP/EB family, member 3".

Further reading[edit]

Juwana JP, Henderikx P, Mischo A, et al. (1999). "EB/RP gene family encodes tubulin binding proteins". Int. J. Cancer. 81 (2): 275–84. doi:10.1002/(SICI)1097-0215(19990412)81:2<275::AID-IJC18>3.0.CO;2-Z. PMID 10188731. S2CID 33232892.
Nakagawa H, Koyama K, Murata Y, et al. (2000). "EB3, a novel member of the EB1 family preferentially expressed in the central nervous system, binds to a CNS-specific APC homologue". Oncogene. 19 (2): 210–6. doi:10.1038/sj.onc.1203308. PMID 10644998. S2CID 2284265.
Su LK, Qi Y (2001). "Characterization of human MAPRE genes and their proteins". Genomics. 71 (2): 142–9. doi:10.1006/geno.2000.6428. PMID 11161807.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bu W, Su LK (2004). "Characterization of functional domains of human EB1 family proteins". J. Biol. Chem. 278 (50): 49721–31. doi:10.1074/jbc.M306194200. PMID 14514668.
Douglas MW, Diefenbach RJ, Homa FL, et al. (2004). "Herpes simplex virus type 1 capsid protein VP26 interacts with dynein light chains RP3 and Tctex1 and plays a role in retrograde cellular transport". J. Biol. Chem. 279 (27): 28522–30. doi:10.1074/jbc.M311671200. PMID 15117959.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mimori-Kiyosue Y, Grigoriev I, Lansbergen G, et al. (2005). "CLASP1 and CLASP2 bind to EB1 and regulate microtubule plus-end dynamics at the cell cortex". J. Cell Biol. 168 (1): 141–53. doi:10.1083/jcb.200405094. PMC 2171674. PMID 15631994.
Yeh TY, Chuang JZ, Sung CH (2005). "Dynein light chain rp3 acts as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway". J. Cell Sci. 118 (Pt 15): 3431–43. doi:10.1242/jcs.02472. PMID 16079286.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000084764 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029166 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9233623-5] Renner C, Pfitzenmeier JP, Gerlach K, Held G, Ohnesorge S, Sahin U, Bauer S, Pfreundschuh M (Aug 1997). "RP1, a new member of the adenomatous polyposis coli-binding EB1-like gene family, is differentially expressed in activated T cells". J Immunol. 159 (3): 1276–83. doi:10.4049/jimmunol.159.3.1276. PMID 9233623. S2CID 23797920.

[entrez-6] "Entrez Gene: MAPRE3 microtubule-associated protein, RP/EB family, member 3".

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