MCR-1
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MCR-1 is a genetic mechanism by which the mcr-1 gene confers the first known plasmid-mediated resistance to colistin, a polymixin and one of a number of last-resort antibiotics.[1][2] The mechanism, first discovered in E. coli (strain SHP45) from a pig in China in November 2015, was later found by independent researchers in human samples from Malaysia, England,[3] China,[4] Europe[5] and the United States.[6] MCR-1 is the first known polymixin resistance mechanism capable of horizontal gene transfer.[1]
See also
References
- ^ a b Liu, YY; Wang, Y; Walsh, TR; Yi, LX; Zhang, R; Spencer, J; Doi, Y; Tian, G; Dong, B; Huang, X; Yu, LF; Gu, D; Ren, H; Chen, X; Lv, L; He, D; Zhou, H; Liang, Z; Liu, JH; Shen, J (18 November 2015). "Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study". The Lancet. Infectious diseases. PMID 26603172.
- ^ Reardon, Sara (21 December 2015). "Spread of antibiotic-resistance gene does not spell bacterial apocalypse — yet". Nature. doi:10.1038/nature.2015.19037.
- ^ "More MCR-1 findings lead to calls to ban ag use of colistin". Retrieved 2015-12-22.
- ^ "Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study - The Lancet Infectious Diseases". www.thelancet.com. doi:10.1016/S1473-3099(15)00424-7. Retrieved 2015-11-19.
- ^ Maryn McKenna. "Apocalypse Pig Redux: Last-Resort Resistance in Europe". Phenomena. Retrieved 28 May 2016.
- ^ The U.S. Military HIV Research Program (MHRP). "First discovery in United States of colistin resistance in a human E. coli infection". www.sciencedaily.com. Retrieved 2016-05-27.
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