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MEAI

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MEAI
Clinical data
Other names5-Methoxy-2-aminoindane; 2,3-Dihydro-5-methoxy-1H-inden-2-amine; MEAI; 5-MeO-AI; Chaperon
Routes of
administration		Oral
ATC code
  • none
Legal status
Legal status
  • Undergoing safety testing
Identifiers
  • 5-Methoxy-2-indanamine
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC10H13NO
Molar mass163.216 g/mol g·mol−1
3D model (JSmol)
  • COC2=CC=C1CC(CC1=C2)N
  • InChI=1S/C10H13NO/c1-12-10-3-2-7-4-9(11)5-8(7)6-10/h2-3,6,9H,4-5,11H2,1H3
  • Key:HLXHCNWEVQNNKA-UHFFFAOYSA-N
 ☒NcheckY (what is this?)  (verify)

5-Methoxy-2-aminoindane (MEAI, 5-MeO-AI, or Chaperon) is a psychoactive small molecule belonging to the aminoindane class with a mechanism of action described by one patent as being mediated by binding to the dopamine D3 receptor.[1]

It was first prepared by Schering AG in 1956.[2] David Nutt and Amanda Feilding filed a patent application for the drug claiming that it gives people a pleasant intoxication as well as prevent binge drinking.[3][4][5]

MEAI has been available through grey market sources since 2011.[6] At least 2 journalists tried it on themselves and reported to the public: Michael Slezak from New Scientist[7] and Brie Traits from BBC3.[8] Apparently, Nutt has also tried it himself.[9]

The idea of alcohol substitution got public attention a year prior to the announcement of chaperon[10] but apparently, chaperon innovates in that it can be consumed together with alcohol without ill effect.[11]

MEAI is banned in some countries as a structural isomer of methcathinone.

See also

References

  1. ^ Haadsma-Svensson, Susanne. "2-aminoindans as selective dopamine D3 ligands".
  2. ^ Verfahren zur Herstellung von analgetisch wirksamen 2-Aminoindanverbindungen, German Patent DE952441, Nov. 15, 1956
  3. ^ Michael Slezak (31 December 2014). "High and dry? Party drug could target excess drinking". New Scientist. Retrieved 31 December 2014.
  4. ^ Gray, Richard. "Could a legal high that mimics ecstasy stop people from boozing? Party drug is patented for use as 'binge mitigation agent'". Daily Mail. Retrieved 19 January 2015.
  5. ^ Theresa, Fisher. "Doctors Have Discovered the Simplest Way to Quit Drinking — By Doing Drugs". Retrieved 19 January 2015.
  6. ^ "5-Meo-AI". Retrieved 31 December 2014.
  7. ^ Slezak, Michael. "A test of chaperon".
  8. ^ Traits, Brie. "How Safe Are My Drugs?". BBC. BBC3.
  9. ^ Phillipa, Skett. "Care for a legal high that's "Chaperon-ed by Imperial"?". Felix Online.
  10. ^ Nutt, David. "Alcohol without the hangover? It's closer than you think". The Guardian.
  11. ^ Cormier, Zoe. "Pop a 'sober up' pill or guzzle synthetic booze to avoid hangovers". The Daily Telegraph. Retrieved 20 January 2015.
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