MIB1

MIB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4TSE, 4XI6, 4XI7, 4XIB
Identifiers
Aliases	MIB1, DIP-1, DIP1, LVNC7, MIB, ZZANK2, ZZZ6, mindbomb E3 ubiquitin protein ligase 1, MIB E3 ubiquitin protein ligase 1
External IDs	OMIM: 608677; MGI: 2443157; HomoloGene: 10810; GeneCards: MIB1; OMA:MIB1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	21,870,953 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	10,818,704 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; tibia; ; nipple; ; caput epididymis; ; parietal pleura; ; corpus callosum; ; visceral pleura; ; secondary oocyte; ; germinal epithelium; ; Achilles tendon;
	Top expressed in
	spermatid; ; parotid gland; ; ciliary body; ; ureter; ; lacrimal gland; ; iris; ; Region I of hippocampus proper; ; spermatocyte; ; conjunctival fornix; ; renal corpuscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; metal ion binding; protein binding; ubiquitin-protein transferase activity; transferase activity;
Cellular component	cytoplasm; cytosol; centrosome; membrane; postsynaptic density; plasma membrane; microtubule organizing center; cytoskeleton; cytoplasmic vesicle;
Biological process	somitogenesis; endocytosis; negative regulation of neuron differentiation; in utero embryonic development; heart looping; positive regulation of endocytosis; heart development; blood vessel development; protein ubiquitination; neural tube formation; Notch signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	57534
	225164
	ENSG00000101752
	ENSMUSG00000024294
	Q86YT6
	Q80SY4
	NM_020774
	NM_144860; NM_001364997
	NP_065825
	NP_659109; NP_001351926
	Wikidata
View/Edit Human	View/Edit Mouse

MIB1 marker also used for detection of grades of astrocytoma

E3 ubiquitin-protein ligase MIB1 is an enzyme that in humans is encoded by the MIB1 gene.^[5] It is involved in regulating apoptosis.^[6]

Confusion with proliferative marker

An antibody directed at the protein Ki-67, a product of the MKI67 gene, is called MIB-1.^[7] The MIB1 gene, which regulates apoptosis, should not be confused with the MIB-1 antibody, which is used to measure Ki-67 expression.

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101752 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024294 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MIB1 mindbomb homolog 1 (Drosophila)".
^ MIB1. OMIM.URL: http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=608677. Accessed on: April 24, 2009.
^ MIB-1. Veripath OncoDiagnostics. http://www.oncodx.org/onco/mib_1.htm. Accessed on: April 24, 2009.

Confusion with proliferative marker

References

Further reading