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MIB1

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This is an old revision of this page, as edited by Daedalus94 (talk | contribs) at 14:42, 18 April 2018 (Removed a statement which seems to have resulted from confusion between the MIB1 gene and MIB-1 proliferation marker.). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

MIB1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesMIB1, DIP-1, DIP1, LVNC7, MIB, ZZANK2, ZZZ6, mindbomb E3 ubiquitin protein ligase 1, MIB E3 ubiquitin protein ligase 1
External IDsOMIM: 608677; MGI: 2443157; HomoloGene: 10810; GeneCards: MIB1; OMA:MIB1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020774

NM_144860
NM_001364997

RefSeq (protein)

NP_065825

NP_659109
NP_001351926

Location (UCSC)Chr 18: 21.7 – 21.87 MbChr 18: 10.73 – 10.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase MIB1 is an enzyme that in humans is encoded by the MIB1 gene.[5] It is involved in regulating apoptosis.[6]

Confusion with proliferative marker

An antibody directed at the protein Ki-67, a product of the MKI67 gene, is called MIB-1.[7] The MIB1 gene, which regulates apoptosis, should not be confused with the MIB-1 antibody, which is used to measure Ki-67 expression.

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References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101752Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024294Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: MIB1 mindbomb homolog 1 (Drosophila)".
  6. ^ MIB1. OMIM.URL: https://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=608677. Accessed on: April 24, 2009.
  7. ^ MIB-1. Veripath OncoDiagnostics. http://www.oncodx.org/onco/mib_1.htm Archived 2006-05-28 at the Wayback Machine. Accessed on: April 24, 2009.

Further reading

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