MYST3

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KAT6A
Protein MYST3 PDB 1m36.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKAT6A, MOZ, MYST3, RUNXBP2, ZC2HC6A, ZNF220, MRD32, MYST-3, lysine acetyltransferase 6A
External IDsMGI: 2442415 HomoloGene: 4924 GeneCards: KAT6A
Gene location (Human)
Chromosome 8 (human)
Chr.Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for KAT6A
Genomic location for KAT6A
Band8p11.21Start41,929,479 bp[1]
End42,051,994 bp[1]
RNA expression pattern
PBB GE MYST3 216361 s at fs.png

PBB GE MYST3 202423 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001099412
NM_001099413
NM_001305878
NM_006766

NM_001081149
NM_001364449

RefSeq (protein)

NP_001292807
NP_006757

NP_001074618
NP_001351378

Location (UCSC)Chr 8: 41.93 – 42.05 MbChr 8: 22.86 – 22.94 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MYST histone acetyltransferase (monocytic leukemia) 3, also known as MYST3, is an enzyme that, in humans, is encoded by the MYST3 gene.[5][6]. This gene is located on the back wing of human chromosome 8, band 8p11.21. [7]

Function[edit]

MYST3 contains two nuclear localization domains, a C2HC3 zinc finger and an acetyltransferase domain. This structure suggests that MYST3 functions as a chromatin-bound acetyltransferase.[6] MYST3 is important for proper development of hematopoietic stem cells.[8]

Alternate Names[edit]

  • KAT6A
  • MOZ
  • MRD32
  • MYST-3
  • ZNF220
  • RUNXBP2
  • ZC2HC6A

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000083168 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031540 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ "Entrez Gene: MYST3 MYST histone acetyltransferase (monocytic leukemia) 3".
  6. ^ a b Borrow J, Stanton VP, Andresen JM, Becher R, Behm FG, Chaganti RS, Civin CI, Disteche C, Dubé I, Frischauf AM, Horsman D, Mitelman F, Volinia S, Watmore AE, Housman DE (September 1996). "The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein". Nat. Genet. 14 (1): 33–41. doi:10.1038/ng0996-33. PMID 8782817.
  7. ^ - KAT6A NCBI
  8. ^ Yang XJ, Ullah M (August 2007). "MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells". Oncogene. 26 (37): 5408–19. doi:10.1038/sj.onc.1210609. PMID 17694082.

Further reading[edit]