MYST3

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KAT6A
Protein MYST3 PDB 1m36.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases KAT6A, MOZ, MYST3, RUNXBP2, ZC2HC6A, ZNF220, MRD32, MYST-3, lysine acetyltransferase 6A
External IDs MGI: 2442415 HomoloGene: 4924 GeneCards: KAT6A
RNA expression pattern
PBB GE MYST3 216361 s at fs.png

PBB GE MYST3 202423 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001099412
NM_001099413
NM_001305878
NM_006766

NM_001081149

RefSeq (protein)

NP_001292807
NP_006757

n/a

Location (UCSC) Chr 8: 41.93 – 42.05 Mb Chr 8: 22.86 – 22.94 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

MYST histone acetyltransferase (monocytic leukemia) 3, also known as MYST3, is an enzyme that, in humans, is encoded by the MYST3 gene.[3][4]

Function[edit]

MYST3 contains two nuclear localization domains, a C2HC3 zinc finger and an acetyltransferase domain. This structure suggests that MYST3 functions as a chromatin-bound acetyltransferase.[4] MYST3 is important for proper development of hematopoietic stem cells.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ "Entrez Gene: MYST3 MYST histone acetyltransferase (monocytic leukemia) 3". 
  4. ^ a b Borrow J, Stanton VP, Andresen JM, Becher R, Behm FG, Chaganti RS, Civin CI, Disteche C, Dubé I, Frischauf AM, Horsman D, Mitelman F, Volinia S, Watmore AE, Housman DE (September 1996). "The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein". Nat. Genet. 14 (1): 33–41. doi:10.1038/ng0996-33. PMID 8782817. 
  5. ^ Yang XJ, Ullah M (August 2007). "MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells". Oncogene. 26 (37): 5408–19. doi:10.1038/sj.onc.1210609. PMID 17694082. 

Further reading[edit]