KAT6A

KAT6A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1M36, 2LN0, 2OZU, 2RC4, 3V43, 4LJN, 4LK9, 4LKA, 4LLB
Identifiers
Aliases	KAT6A, MOZ, MYST3, RUNXBP2, ZC2HC6A, ZNF220, MRD32, MYST-3, lysine acetyltransferase 6A, ARTHS
External IDs	OMIM: 601408; MGI: 2442415; HomoloGene: 4924; GeneCards: KAT6A; OMA:KAT6A - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	42,051,994 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	23,433,275 bp
RNA expression pattern
	Top expressed in
	nipple; ; internal globus pallidus; ; lactiferous duct; ; skin of arm; ; skin of thigh; ; mucosa of ileum; ; skin of hip; ; epithelium of colon; ; cardia; ; vulva;
	Top expressed in
	Gonadal ridge; ; retinal pigment epithelium; ; molar; ; tibiofemoral joint; ; lacrimal gland; ; left lung lobe; ; cerebellar vermis; ; vas deferens; ; ciliary body; ; blood;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; DNA binding; transcription coactivator activity; transcription factor binding; metal ion binding; histone acetyltransferase activity; protein binding; acyltransferase activity; acetyltransferase activity; zinc ion binding; H4 histone acetyltransferase activity; histone binding;
Cellular component	PML body; nucleosome; MOZ/MORF histone acetyltransferase complex; nucleus; nucleoplasm; nucleolus; cytosol; nuclear speck; histone acetyltransferase complex;
Biological process	animal organ development; nucleosome assembly; myeloid cell differentiation; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription, DNA-templated; cellular senescence; histone H3 acetylation; negative regulation of transcription, DNA-templated; protein acetylation; regulation of signal transduction by p53 class mediator; histone acetylation; chromatin organization; histone H4 acetylation; positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	7994
	244349
	ENSG00000083168
	ENSMUSG00000031540
	Q92794
	Q8BZ21
	NM_001099412; NM_001099413; NM_001305878; NM_006766
	NM_001081149; NM_001364449
	NP_001292807; NP_006757
	NP_001074618; NP_001351378
	Wikidata
View/Edit Human	View/Edit Mouse

MYST histone acetyltransferase (monocytic leukemia) 3, also known as MYST3, is an enzyme that, in humans, is encoded by the MYST3 gene.^[5]^[6]. This gene is located on the back wing of human chromosome 8, band 8p11.21. ^[7]

Function

MYST3 contains two nuclear localization domains, a C₂HC₃ zinc finger and an acetyltransferase domain. This structure suggests that MYST3 functions as a chromatin-bound acetyltransferase.^[6] MYST3 is important for proper development of hematopoietic stem cells.^[8]

Alternate Names

KAT6A
MOZ
MRD32
MYST-3
ZNF220
RUNXBP2
ZC2HC6A

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000083168 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031540 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: MYST3 MYST histone acetyltransferase (monocytic leukemia) 3".
^ ^a ^b Borrow J, Stanton VP, Andresen JM, Becher R, Behm FG, Chaganti RS, Civin CI, Disteche C, Dubé I, Frischauf AM, Horsman D, Mitelman F, Volinia S, Watmore AE, Housman DE (September 1996). "The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein". Nat. Genet. 14 (1): 33–41. doi:10.1038/ng0996-33. PMID 8782817.
^ - KAT6A NCBI
^ Yang XJ, Ullah M (August 2007). "MOZ and MORF, two large MYSTic HATs in normal and cancer stem cells". Oncogene. 26 (37): 5408–19. doi:10.1038/sj.onc.1210609. PMID 17694082.

Function

Alternate Names

References

Further reading