Magnetic particle imaging
Magnetic particle imaging (MPI) is a tomographic imaging technique that measures the magnetic fields generated by superparamagnetic nanoparticles (iron oxide) as tracers. Researchers at Philips Research have used the technique to achieve resolutions finer than one millimeter. Magnetic particle imaging has potential applications in medicine and material science. Recently, the first in-vivo results were published revealing structures of a beating mouse heart.
In 2001, researchers at the Royal Philips Research Lab in Hamburg came up with the initial concept of MPI. In 2005, they created and started testing with their first MPI scanner set up. By 2009, the blood flow and organs within mice were successfully imaged.
The superparamagnetic nanofluid used in magnetic particle imaging is superparamagnetic iron oxide (SPIO). This fluid is very responsive to even weak magnetic fields, and all of the magnetic moments will line up in the direction of an induced magnetic field. These particles can be used because the human body does not contain anything which will create magnetic interference in imaging.
- High resolution (~0.4 mm)
- Fast image results (~20 ms)
- No radiation
- No iodine
- No background noise (high contrast)
- "Nature 435, 1214–1217 (02005_06_30)"
- "Three-dimensional real-time in vivo magnetic particle imaging"
- "Magnetic Particle Imaging (MPI) at RWTH Aachen University"
- "MPI work at University of California, Berkeley"
- "MPI research at University of Lübeck"
- "Philips announces breakthrough in medical imaging technology"
- Knopp, Tobias, Buzug, Thorsten M.: Magnetic Particle Imaging. An Introduction to Imaging Principles and Scanner Instrumentation, ISBN 978-3-642-04198-3
- Magnetic Insight, Inc. - Commercializing MPI technology originally developed at the University of California, Berkeley 11/2014
- J.-P. Gehrcke. Characterization of the Magnetic Particle Imaging Signal Based on Theory, Simulation, and Experiment. M. Sc. thesis, University of Würzburg, 2010.
- Magnetic particle imaging: moving ahead, medicalphysicsweb.org Apr 12, 2011
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