Mantle zone

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Mantle zone
Image labeled in German, but "Mantel-zone" visible near center.
Anatomical terminology

The mantle zone (or just mantle) of a lymphatic nodule (or lymphatic follicle) is an outer ring of small lymphocytes surrounding a germinal center.[1]

It is also known as the "corona".[2]

It contains transient lymphocytes.[3]

It is the location of the lymphoma in mantle cell lymphoma.


Intermediate magnification micrograph of Castleman disease showing the characteristic expansion of the mantle zone. H&E stain.

Mantle zone expansion may be seen in benign, such as Castleman disease, and malignancy, i.e., Mantle cell lymphoma. Tcl-1 is expressed in the mantle zone.


  1. ^ "Archived copy". Archived from the original on 2008-06-03. Retrieved 2008-07-29.
  2. ^ "Archived copy". Archived from the original on 2008-03-17. Retrieved 2008-07-29.
  3. ^

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